Does multivariate pattern analysis of functional magnetic resonance data benefit from high resolution and sensitivity at high magnetic field strength (7T)?

功能磁共振数据的多变量模式分析是否受益于高磁场强度 (7T) 下的高分辨率和灵敏度？

• 批准号: 233174194
• 负责人: Professor Dr. Stefan Pollmann
• 金额: --
• 依托单位: Lehrstuhl für Allgemeine Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/233174194?language=en
• 关键词: Does; multivariate; pattern; analysis; functional

Multivariate pattern analysis (MVPA) of functional magnetic resonance data has recently been widely used in the neurosciences. MVPA promises to yield information about brain function with high spatial resolution. Recently, however, conflicting results were published concerning the information carried by functional magnetic resonance data at different spatial scales and their contribution to classification analyses. In the present project, we intend to investigate to what degree the high spatial resolution and sensitivity yielded at high magnetic field strength contributes to an improved classification of functional activation patterns. To this end we vary field strength (3T and 7T), spatial resolution and sensitivity and investigate their influence under stimulation conditions that create neuronal excitation patterns in the sub-millimeter versus multiple-millimeter scale. The overall goal of the project is the characterization of factors influencing multivariate pattern analysis of functional magnetic resonance data and, subsequently, the optimization of future experimental designs using MVPA.

功能磁共振数据的多元模式分析（MVPA）近年来在神经科学中得到了广泛的应用。MVPA有望以高空间分辨率获得有关大脑功能的信息。然而，关于不同空间尺度的功能磁共振数据所携带的信息及其对分类分析的贡献，最近发表的结果相互矛盾。在本项目中，我们打算研究在高磁场强度下产生的高空间分辨率和灵敏度在多大程度上有助于改进功能激活模式的分类。为此，我们改变了场强（3T和7T）、空间分辨率和灵敏度，并研究了它们在亚毫米和多毫米尺度上产生神经元兴奋模式的刺激条件下的影响。该项目的总体目标是表征影响功能磁共振数据多元模式分析的因素，并随后使用MVPA优化未来的实验设计。

项目成果

The effect of acquisition resolution on orientation decoding from V1 BOLD fMRI at 7T

采集分辨率对 7T V1 BOLD fMRI 方向解码的影响

• DOI: 10.1016/j.neuroimage.2016.12.040
• 发表时间: 2017
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Sengupta;Yakupov;Pollmann
• 通讯作者: Pollmann

The effect of acquisition resolution on orientation decoding from V1: comparison of 3T and 7T

V1 采集分辨率对方向解码的影响：3T 和 7T 的比较

• DOI: 10.1101/305417
• 期刊: bioRxiv
• 作者: Sengupta;Yakupov;Kanowski;Tempelmann;Pollmann
• 通讯作者: Pollmann