LOCALIZATION OF NEUROPEPTIDE Y MRNA BY IN-SITU HYBRIDIZATION

通过原位杂交对神经肽 Y mRNA 进行定位

• 批准号: 3966599
• 负责人: D G GEHLERT
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3966599
• 关键词: brain mapping; hypothalamus; messenger RNA

I have demonstrated the distribution of neuropeptide Y (NPY) mRNA in the brain. NPY mRNA containing cell bodies are found primarily in the arcuate nucleus of the hypothalamus but can also be found scattered in the cortex, caudate-Putamen and nucleus accumbens. The distribution of NPY mRNA containing neurons correlates well with the distribution of immunohistochemically detected NPY. These results indicate that the arcuate nucleus of the hypothalamus is a key region for the central actions of NPY.

我已经证明了神经肽Y（NPY）mRNA在脑组织中的分布， 个脑袋 含有NPY mRNA的细胞体主要在弓状核中发现， 下丘脑的核，但也可以发现分散在皮层， 尾状核-壳核和尾状核。 NPY mRNA的分布 含有神经元的神经元与 免疫组织化学检测NPY。 这些结果表明 下丘脑弓状核是中枢活动的关键部位 的NPY。