The NCJDSU Tissue Resource: support for continued banking activities

NCJDSU 组织资源：支持持续的银行活动

• 批准号: G0900580/1
• 负责人: James Ironside
• 金额: $ 23.78万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900580%2F1
• 关键词: NCJDSU; Tissue; Resource; support; continued

Prion diseases are fatal disorders that affect the brain, and include conditions such as BSE or ?mad cow disease? in cattle and Creutzfeldt-Jakob disease (CJD) in humans. One form of CJD, known as variant CJD, is linked to exposure to BSE through the diet. Prion diseases are transmissible, and studies of CJD and BSE have shown that the infectious agent accumulates at highest levels in the brain. However, the agent can also be present in a range of other tissues throughout the body. The aim of this research is to continue the collection and storage of tissues from all forms of CJD in a brain and tissue bank in the National CJD Surveillance Unit, Edinburgh. This bank played a key role in the discovery of variant CJD, and is in continuing use by a wide range of researchers in UK and across the world. The material collected comes from tissue and organs taken at autopsy from patients with suspected CJD only when the relatives have given consent. We also collect blood and CSF samples from living patients, again with consent. The bank has approval for this work from our local Ethical Committee, and has been used for many research projects, resulting in major scientific and medical publications. The information from this research has also made a big impact on the work of the NHS, particularly in steps to reduce the chance of transmission of variant CJD by blood transfusion and by surgical instruments. We believe that the bank will continue to be needed by researchers in the UK and elsewhere in the future, since there are so many unanswered questions about this group of diseases. There is also a major need to help develop a test for CJD that can be used on living patients, which will be helped by the use of the tissue and blood samples in our bank. We run the bank according to MRC guidelines, and use a Steering Committee (that includes 2 members of the public) to oversee our work. The results from our work are presented in many forms, such as scientific and medical papers, lectures (including public lectures) and in interviews with the press, radio and television.

Prion病是影响大脑的致命疾病，包括疯牛病或疯牛病？牛和人类的克雅病(CJD)。一种形式的CJD被称为变异型CJD，与通过饮食接触疯牛病有关。Prion疾病是可以传播的，对CJD和BSE的研究表明，这种感染性病原体在大脑中积聚的水平最高。然而，该制剂也可以存在于全身其他一系列组织中。这项研究的目的是继续收集和储存来自所有形式的CJD的组织，并将其存储在爱丁堡国家CJD监测单位的大脑和组织库中。这家银行在发现CJD变种的过程中发挥了关键作用，并被英国和世界各地的广泛研究人员继续使用。收集的材料来自尸检时从疑似CJD患者身上提取的组织和器官，只有在亲属同意的情况下才会如此。我们还收集活着的患者的血液和脑脊液样本，同样是在征得同意的情况下。该银行的这项工作得到了我们当地伦理委员会的批准，并被用于许多研究项目，产生了重大的科学和医学出版物。这项研究的信息也对NHS的工作产生了重大影响，特别是在减少通过输血和手术器械传播变异CJD的机会方面。我们相信，英国和其他地方的研究人员未来将继续需要这家银行，因为关于这类疾病有太多悬而未决的问题。还需要帮助开发一种可用于活体患者的CJD检测方法，这将得益于我们银行的组织和血液样本的使用。我们根据MRC的指导方针运营银行，并使用一个指导委员会(包括2名公众成员)来监督我们的工作。我们的工作成果以多种形式呈现，如科学和医学论文、讲座(包括公开讲座)以及接受媒体、广播和电视采访。