CENTER FOR CLINICAL RESEARCH IN EPILEPSY

这项临床中心拨款提案的中心主题是临床 癫痫现象。这是一项庞大而复杂的提案，旨在 生成的29个单独建议的交错 庞大而广泛的多学科临床科学家群体。因此， 建议的研究包括对几种具体形式的 成人和儿童的药物治疗，包括评估和 抗惊厥新药的临床试验。一系列详细的 建议进行药代动力学研究，并检查几个 药物的生物学后果，包括怀孕期间的变化。 临床神经生理学的研究包括发展脑电的尝试 癫痫发作频率的预测指标，计算机分析各种因素 对电生理放电、行为激活脑电有改善作用 诊断分辨率以及语言本地化的脑电研究 可能在治疗外科判断中产生重要的后果。 提高诊断能力的放射学技术包括使用 CT扫描以解决有关定位的歧义，并有望 协助诊断切迹硬化症。癫痫发作的频率 提出了各种有趣的统计问题和计算机建模 将检查癫痫发作频率以及其他统计研究 得了癫痫。这些延伸到几个流行病学的实地研究。 现象以及特定环境因素的作用，如 应激和抑郁作为癫痫发作频率的决定因素。是这样的 神经心理学研究延伸到康复领域 在那里，将进行最佳技术的对照研究 评估就业安置的能力和成本效益 具体的康复措施以及消费者的参与。 最后，研究确定了各种教育的有效性 涉及公众和医疗专业的技术包括 建议在疗养院和癫痫患者中开展教育工作 这条信息专线有望揭开那些最高 优先考虑癫痫患者。因此，存在着广泛的 项目范围从生物学研究到心理社会领域。

The central theme of this Clinical Center Grant proposal is the clinical phenomenon of Epilepsy. It is a large, complex proposal designed to indicate the interdigitations of 29 individual proposals generated by a large and broad group of multidisciplinary clinical scientists. Thus, the proposed studies include evaluations of several specific forms of pharmacological therapy in adults and children including the evaluation and clinical trial of new anticonvulsant drugs. A series of detailed pharmacokinetic studies are proposed as well as examination of several biological consequences of drugs including changes during pregnancy. Studies in clinical neurophysiology include an attempt to develop EEG predictors of seizure frequency, computer analysis of various elements of the electrophysiological discharge, behavioral activation of EEG to improve diagnostic resolution as well as EEG studies of language localization which can have important consequences in theraputic surgical judgements. Radiologic techniques to improve diagnostic capabilities include the use of the CT scan to resolve ambiguities regarding localization and hopefully to assist in the diagnosis of incisural sclerosis. Frequency of seizures raises a variety of interesting statistical questions and computer modeling of seizure frequency will be examined as well as other statistical studies in epilepsy. These extend into several field studies of epidemiological phenomena as well as the roles of specific enviornmental factors such as stress and depression as determinates of seizure frequency. Such neuropsychological investigations extend into the area of rehabilitation where controlled studies will be undertaken of optimal techniques for evaluating capabilities for job placement and the cost effectiveness of specified rehabilitation measures as well as consumer involvement. Finally, studies to determine the effectiveness of various educational techniques involving both the public as well as the medical profession are proposed including educational efforts in nursing homes and an epilepsy information line which will hopefully uncover those problems of highest priority to patients with epilepsy. Thus, there is a broad spectrum of projects ranging from biological studies to those in the psychosocial area.