Nucleic Acid Aptamers As Research Tools And Diagnostic Reagents In Amyloid Disease

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A number of major diseases such as Alzheimer s are now known to be caused by an error in the behaviour of the proteins within our bodies. Normally soluble proteins become sticky and begin to clump together forming aggregates called amyloid. This clumping process causes damage to the tissues within the body, for example the death of brain cells in Alzheimer s disease resulting in memory loss and ultimately dementia. We are proposing to produce molecules that in the long term could be used by doctors to screen for the presence of amyloid, allowing early detection and possibly even treatment of these devastating diseases.