MMP-12-mediated vascular elastolysis - a potential target for therapeutic intervention in complicated pregnancies

MMP-12介导的血管弹性溶解——复杂妊娠治疗干预的潜在目标

• 批准号: G0900991/1
• 负责人: John Aplin
• 金额: $ 29.02万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900991%2F1
• 关键词: MMP; 12; mediated; vascular; elastolysis

Normally, blood flow is controlled by stretchy, elastic fibres in the walls of blood vessels that allow them to become wider or narrower, as required. In pregnancy, the developing baby needs a constant supply of blood, so elastic fibres in the blood vessels of the womb are broken down and the vessels are permanently widened. If this process does not happen, it can cause the baby to be born too small or too early and can make the mother seriously ill. We have identified one of the proteins that controls breakdown of elastic fibres in the womb and we will study different ways to increase its activity. This will lead to development of a treatment to make blood vessels in the womb wider, if the process does not happen naturally.

正常情况下，血液流动是由血管壁中的弹性纤维控制的，这些纤维允许血管根据需要变得更宽或更窄。在怀孕期间，发育中的婴儿需要持续的血液供应，因此子宫血管中的弹性纤维被破坏，血管永久性地变宽。如果这个过程没有发生，它可能会导致婴儿出生太小或太早，并可能使母亲患重病。我们已经确定了一种控制子宫内弹性纤维分解的蛋白质，我们将研究不同的方法来增加其活性。这将导致开发一种治疗方法，使子宫内的血管更宽，如果这个过程不是自然发生的话。