A CLINICAL RESEARCH PROGRAM FOR THE PARTIAL EPILEPSIES

部分性癫痫的临床研究计划

• 批准号: 3099225
• 负责人: JEROME NONE ENGEL
• 金额: $ 90.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099225
• 关键词: electroencephalography; human subject; partial seizure; psychobiology; temporal lobe /cortex disorder

The Clinical Neurophysiology Program (CNP) at UCLA makes use of the unique opportunities provided by an epilepsy surgery facility to carry out research on the human brain. In the past, emphasis was placed on clinical research directed toward improving the diagnosis and surgical treatment of epilepsy, although basic research has always been an important part of the program. More recently, resective surgery has become sufficiently accepted as a safe and effective mode of treatment for partial epilepsy to allow clinical activities of the CNP to be supported by hospital funds or supplemented by grants awarded to develop specific diagnostic techniques. In this research proposal we are requesting support only for basic research projects that take advantage of knowledge gained from animal studies and the clinical setting to investigate fundamental mechanisms of normal and abnormal human brain function. Information obtained from patients in our epilepsy surgery facility will be utilized by a multidisciplinary team of basic and clinical neuroscientists to define anatomical and physiological substrates of normal and epileptiform cerebral processes, and to determine how epilepsy related pathological processes might interfere with normal neuronal integration to disrupt behavior during, and between seizures. Specifically, we propose to examine alterations in cellular morphology in epileptogenic tissue and relate these findings to neurotransmitter function, to neuronal activity at the unit level, and to quantitative analysis of spontaneous and stimulation induced field potentials. We also propose to examine anatomical and physiological substrates of sensory processing, memory, and control of cardiorespiratory function. The long term objectives of the CNP are: a. to reveal mechanisms of epileptogenesis in order to suggest new medical, as well as surgical approaches to antiepileptic therapy; b. to better understand the neuronal basis of normal human behavior and mechanisms of pathological disruption that result in abnormal behavior, in order to prevent or more effectively treat behavioral disturbances associated with epilepsy and other neurological disorders; and c. to establish the most effective and efficient presurgical evaluation protocol for epileptic patients who are candidates for resective surgery, in order to allow the greatest number of patients to benefit from this procedure.

加州大学洛杉矶分校的临床神经生理学课程(CNP)利用独特的 由癫痫外科机构提供的实施 对人脑的研究。过去，重点放在临床上 旨在提高诊断和外科治疗水平的研究 癫痫，尽管基础研究一直是 程序。最近，切除手术已被广泛接受。 作为一种安全有效的治疗部分性癫痫的模式 CNP的临床活动将由医院资金或 此外，还提供了用于开发特定诊断技术的赠款。 在这项研究提案中，我们只要求对基础研究提供支持 利用从动物研究中获得的知识和 研究正常和慢性阻塞性肺疾病基本发病机制的临床环境 人脑功能异常。从本署的病人处取得的资料 癫痫手术设施将由一个多学科团队使用 基础和临床神经学家定义解剖学和生理学 正常和癫痫样脑突起的底物，并确定 癫痫相关的病理过程可能如何干扰正常 神经元整合，以破坏癫痫发作期间和发作之间的行为。 具体地说，我们建议检查细胞形态的变化 致痫组织并将这些发现与神经递质相关 功能，神经元在单位水平的活动，以及数量 自发和刺激诱发场电位的分析。我们也 建议研究感觉的解剖学和生理学基础 心肺功能的处理、记忆和控制。《长河》 CNP的长期目标是：A.揭示癫痫发生的机制 为了建议新的医学和外科方法 抗癫痫治疗；B.更好地了解正常的神经元基础 导致人类行为和病理破坏的机制 异常行为，以预防或更有效地治疗行为 与癫痫和其他神经疾病有关的障碍；以及 C.建立最有效和最高效的术前评估 适用于手术切除的癫痫患者的方案， 为了让最大数量的患者从中受益 程序。