APOLIPOPROTEIN METABOLISM: REGULATION AND FUNCTION

激素和营养物质对载脂蛋白代谢的影响将是 使用三种主要的动物模型进行检验：(1)大鼠，(2)狗，(3)帕塔斯 猴子。这三个动物模型的使用将提供特定的信息 哺乳动物脂蛋白中物种效应与一般效应的比较 生理学。血液和外周血中载脂蛋白及脂质成分的研究 将对淋巴进行研究，以确定激素、营养素之间的关系 和脂蛋白在这些介质中的代谢。对这些过程的调查将 在动物体内进行体外酶分析、肝脏灌流和 培养的肝细胞。将利用免疫化学的新技术来 扩展我们的能力，研究脂蛋白的组成、代谢和 结构。这些研究将使我们更好地了解 高脂血症患者激素、营养与载脂蛋白代谢的关系 血液和淋巴。这些结果将有助于我们理解 动脉粥样硬化的发展、防治。

The effects of hormones and nutrients on apolipoprotein metabolism will be examined by using three major animal models: (1) rat, (2) dog, and (3) patas monkey. The use of the three animal models will afford information on specific effects for the species versus general effects in mammalian lipoprotein physiology. The apolipoprotein and lipid composition of blood and peripheral lymph will be studied to determine the relationship between hormones, nutrients and lipoprotein metabolism in these media. Investigations of the processes will be conducted in animals with in vitro enzyme assays, liver perfusions, and cultured hepatocytes. New techniques in immunochemistry will be utilzed to expand our capabilities to study lipoprotein composition, metabolism and structure. These studies will provide a better understanding of the relationship between hormones, nutrients, and apolipoprotein metabolism in the blood and lymph. These results will help in our understanding of the development of atherosclerosis, its prevention and its treatment.