APOLIPOPROTEIN METABOLISM: REGULATION AND FUNCTION

激素和营养素对载脂蛋白代谢的影响将 通过使用三种主要动物模型进行检查：（1）大鼠，（2）犬，和（3）鱼 猴子. 三种动物模型的使用将提供关于特定的 种属效应与哺乳动物脂蛋白中的一般效应 physiology. 血液及外周血载脂蛋白和脂质组成 淋巴将被研究，以确定激素，营养素， 和脂蛋白代谢。 对过程的调查将 在动物中进行体外酶测定、肝灌注，以及 培养的肝细胞。 免疫化学的新技术将用于 扩大我们的能力，研究脂蛋白组成，代谢和 结构 这些研究将使人们更好地了解 激素、营养素和载脂蛋白代谢之间的关系 血液和淋巴 这些结果将有助于我们了解 动脉粥样硬化的发展，其预防和治疗。

The effects of hormones and nutrients on apolipoprotein metabolism will be examined by using three major animal models: (1) rat, (2) dog, and (3) patas monkey. The use of the three animal models will afford information on specific effects for the species versus general effects in mammalian lipoprotein physiology. The apolipoprotein and lipid composition of blood and peripheral lymph will be studied to determine the relationship between hormones, nutrients and lipoprotein metabolism in these media. Investigations of the processes will be conducted in animals with in vitro enzyme assays, liver perfusions, and cultured hepatocytes. New techniques in immunochemistry will be utilzed to expand our capabilities to study lipoprotein composition, metabolism and structure. These studies will provide a better understanding of the relationship between hormones, nutrients, and apolipoprotein metabolism in the blood and lymph. These results will help in our understanding of the development of atherosclerosis, its prevention and its treatment.