Significance of efflux pumps in multidrug resistance and pathogenesis of Acinetobacter spp.

外排泵在不动杆菌属多重耐药性和发病机制中的意义。

• 批准号: G0901366/1
• 负责人: Laura Piddock
• 金额: $ 17.44万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901366%2F1
• 关键词: Significance; efflux; pumps; multidrug; resistance

Hospital-acquired infections caused by Acinetobacter spp. are a serious problem especially in the burns and intensive care units because of the rapid increase in Acinetobacter spp. that have become resistant to multiple antibiotics. In this project, we will perform experiments that will allow us to understand how multi-resistance to antibiotics is caused. We will focus on broad substrate-specificity efflux pumps that actively export the drugs, thus rendering them less effective. We want to know the contribution of increased efflux pump activities in the development of multi-drug resistance in Acinetobacter spp. in the clinical environment. We anticipate that we will discover physiological substrates of these pumps and the biochemical pathways that produce them. This could lead to the discovery of novel antimicrobials and inhibitors of the broad-spectrum efflux pumps.

不动杆菌属引起的医院获得性感染是一个严重的问题，特别是在烧伤和重症监护病房，因为不动杆菌属的迅速增加。对多种抗生素产生了抗药性在这个项目中，我们将进行实验，使我们能够了解对抗生素的多重耐药性是如何引起的。我们将专注于广泛的底物特异性外排泵，积极输出的药物，从而使他们不那么有效。我们想知道外排泵活性增加在不动杆菌多重耐药发展中的作用。在临床环境中。我们预计，我们将发现这些泵的生理底物和产生它们的生化途径。这可能会导致新型抗菌药物和广谱外排泵抑制剂的发现。