Human Natural Killer cell-related receptors: diversity, ligands and disease susceptibility.

人类自然杀伤细胞相关受体：多样性、配体和疾病易感性。

• 批准号: G0901682-E01/1
• 负责人: John Trowsdale
• 金额: $ 190.51万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901682-E01%2F1
• 关键词: Human; Natural; Killer; cell; related

Natural killer cells provide defence for your body against viruses and tumours. These cells have proteins on their surfaces, which allow them to detect cells that are infected or cancerous. This programme of research will examine these proteins in detail. We will find out how they differ between different people as this may help to understand why some people are susceptible to certain diseases. We also determine what the proteins are interacting with, in other words, their target molecules. This will help to understand how an infected or cancerous cell is recognised by the immune system.

自然杀伤细胞为您的身体提供防御病毒和肿瘤。这些细胞表面有蛋白质，这使它们能够检测到被感染或癌变的细胞。这项研究计划将详细研究这些蛋白质。我们将找出不同人之间的差异，因为这可能有助于理解为什么有些人容易患某些疾病。我们还确定蛋白质与什么相互作用，换句话说，它们的靶分子。这将有助于了解免疫系统如何识别感染或癌细胞。