Human Natural Killer cell-related receptors: diversity, ligands and disease susceptibility.

人类自然杀伤细胞相关受体：多样性、配体和疾病易感性。

• 批准号: G0401569/1
• 负责人: John Trowsdale
• 金额: $ 127.42万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0401569%2F1
• 关键词: Human; Natural; Killer; cell; related

Natural Killer Cells circulate in the blood. They have an important role in protection against infection and cancer. It is not well understood how Natural Killer Cells achieve the difficult task of attacking infected tissue but leaving normal tissues alone; it is suspected that receptor molecules on the surface of the cells play a critical role. One set of receptors, called KIR, differ dramatically from person to person. This striking feature provides clues to their functions in immune defence.In view of this, our project has three aims:To investigate the dramatic variation in KIR receptors from person to person.To identify what different KIR receptors bind to on cells that they target; what are they receptors of?To understand how variation in KIR receptors helps some people to be resistant to disease. By understanding how KIR receptors work we hope to be able to harness them to combat cancer and infection.

自然杀伤细胞在血液中循环。它们在预防感染和癌症方面发挥着重要作用。目前尚不清楚自然杀伤细胞如何完成攻击感染组织但不攻击正常组织的艰巨任务；人们怀疑细胞表面的受体分子发挥了关键作用。一组称为KIR的受体因人而异。这一显著的特征为它们在免疫防御中的功能提供了线索。有鉴于此，我们的项目有三个目标：研究KIR受体在人与人之间的显著差异；确定不同的KIR受体与它们所针对的细胞结合的不同；它们是什么受体？了解KIR受体的变化如何帮助一些人对疾病产生抵抗力。通过了解KIR受体的工作原理，我们希望能够利用它们来对抗癌症和感染。