Mycobacterium tuberculosis capsular alpha-glucan biosynthesis and characterisation of host-pathogen interactions

结核分枝杆菌荚膜α-葡聚糖生物合成和宿主-病原体相互作用的表征

• 批准号: G0901690/1
• 负责人: Gurdyal Besra
• 金额: $ 50.55万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901690%2F1
• 关键词: Mycobacterium; tuberculosis; capsular; alpha; glucan

Like many bacterial species, Mycobacterium tuberculosis, the bacterium that causes TB, is covered with an outer capsule composed of sugar polymers. These so called sugar capsules have been shown to be important for bacterial virulence by undermining the host immune response. Although, the composition of the M. tuberculosis capsule isrelatively well studied, the mechanism underlying its production and its functional role have only been poorly defined. The aim of this project is to obtain an insight into these two important issues. Firstly, we will address, in detail, the route by which the capsule is produced, and secondly, we will study the capsule?s functional role under variousexperimental conditions. Together, the data will provide valuable insight into the nature and function of this long neglected structure.

像许多细菌物种一样，结核分枝杆菌（导致结核病的细菌）被一种由糖聚合物组成的外囊所覆盖。这些所谓的糖胶囊已被证明是重要的细菌毒力破坏宿主的免疫反应。虽然M.结核包膜的研究相对较好，但其产生机制及其功能作用的定义尚不明确。本项目的目的是深入了解这两个重要问题。首先，我们将详细说明胶囊的生产路线，其次，我们将研究胶囊。的功能作用在各种实验条件下。总之，这些数据将为这个长期被忽视的结构的性质和功能提供有价值的见解。