"Concealed Cardiomyopathy" and Sudden Cardiac Death

“隐匿性心肌病”和心脏性猝死

• 批准号: nhmrc : 2003997
• 金额: $ 117.48万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/concealed-cardiomyopathy-sudden-cardiac-death/1780266
• 关键词: Concealed; Cardiomyopathy; Sudden; Cardiac; Death

Sudden cardiac death (SCD) is a devastating consequence of a number of heart diseases. Underlying causes include inherited heart muscle problems (cardiomyopathies), with no cause found in 40%. Our study will investigate the role of 'concealed cardiomyopathy' cases, i.e. those with a SCD event with no evidence of heart disease, but carry errors in heart genes. Our findings will translate rapidly into more targeted clinical and genetic evaluation of families with the ultimate goal to prevent SCD.

心脏性猝死(SCD)是许多心脏疾病的毁灭性后果。潜在的原因包括遗传性心肌问题(心肌病)，40%的人没有发现原因。我们的研究将调查隐匿性心肌病病例的作用，即那些有SCD事件但没有心脏病证据，但携带心脏基因错误的病例。我们的发现将迅速转化为对家庭进行更有针对性的临床和基因评估，最终目标是预防SCD。