Investigating the functions and therapeutic potential for Eph receptors and ephrins during wound repair and inflammation
研究 Eph 受体和肝配蛋白在伤口修复和炎症过程中的功能和治疗潜力
基本信息
- 批准号:G0901822/1
- 负责人:
- 金额:$ 74.3万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2010
- 资助国家:英国
- 起止时间:2010 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Wound healing is the body?s process of repairing damaged tissue and takes place for all wounds, be they a nick to the finger or the repair of internal organs after abdominal surgery. There are many occasions when tissue repair fails, leading to chronic non-healing wounds such as venous leg ulcers which are a huge clinical burden for elderly patients and suffered by about 500,000 people in the UK. Equally, the process can be too exuberant leading to fibrosis and scarring as a consequence of excessive contraction, healing and inflammation. In order to understand how tissue repair goes awry and how it might be improved, we need to better understand the process, and essentially that means figuring out how the dormant tissues of unwounded skin (or other organs), are awakened upon damage, allowing them to migrate and fill the gap created by the wound, and how they know when to stop when the wound is healed.The studies outlined here are to investigate a family of receptors and the proteins that bind to them, the Ephs and ephrins, that, despite being very well studied in embryonic development and in cancer and implicated in regulating the ?starting and stopping? of cell migrations in both these scenarios, have not previously been studied in the wound repair process. We have preliminary data in mouse that shows how several members of this large family of receptors become expressed and activated in particular cell types during the wound closure process, in ways that are suggestive of their being key players, and we will look to see whether the same is true in human wound tissues and whether biopsies from pathological wounds, in particular longstanding leg ulcers, have an altered pattern of these receptors. We will then test whether modulating particular Eph family members will allow us to alter and improve some aspects of healing while not affecting others, with a view to designing therapies that can either ?kickstart? the tissues of a non-healing wound to repair itself or shut down the repair machinery in a wound that is too inflamed and/or too exuberant and likely to form a bad scar.
伤口愈合是身体吗?它是修复受损组织的过程,适用于所有伤口,无论是手指上的划痕还是腹部手术后的内脏修复。在许多情况下,组织修复失败,导致慢性不愈合伤口,如静脉性腿部溃疡,这对老年患者来说是一个巨大的临床负担,在英国约有50万人患有这种疾病。同样,该过程可能过于旺盛,导致纤维化和疤痕,作为过度收缩、愈合和炎症的结果。为了了解组织修复是如何出错的,以及如何改进,我们需要更好地了解这个过程,本质上这意味着要弄清楚未受伤皮肤的休眠组织是如何(或其他器官)在损伤时被唤醒,允许它们迁移并填充由伤口产生的差距,以及伤口愈合后它们如何知道何时停止。这里概述的研究是为了研究受体家族以及与它们结合的蛋白质,即Ephs和肝配蛋白,即,尽管在胚胎发育和癌症中已经有了很好的研究,并且涉及到调节?开始和停止?在这两种情况下的细胞迁移,以前没有在伤口修复过程中进行过研究。我们在小鼠中获得的初步数据显示,在伤口闭合过程中,这个受体大家族的几个成员是如何在特定细胞类型中表达和激活的,其表达方式表明它们是关键参与者,我们将研究人类伤口组织是否也是如此,以及病理伤口的活检,特别是长期的腿部溃疡,是否改变了这些受体的模式。然后,我们将测试是否调节特定的Eph家族成员将允许我们改变和改善愈合的某些方面,而不影响其他方面,以期设计治疗,可以?kickstart?不愈合伤口的组织进行自我修复,或者关闭伤口中的修复机制,该修复机制过于发炎和/或过于旺盛,并且可能形成严重的疤痕。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Martin其他文献
The search for environmental justice
寻求环境正义
- DOI:
10.4337/9781784719425.00006 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Paul Martin;S. Bigdeli;T. Daya;W. D. Plessis;A. Kennedy - 通讯作者:
A. Kennedy
The influence of health concerns in scientific and policy debates on climate change
健康问题对气候变化科学和政策辩论的影响
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:6.3
- 作者:
F. Fabrizi;G. Lunghi;Paul Martin;F. Poordad - 通讯作者:
F. Poordad
Natural-series radionuclides in traditional North Australian aboriginal foods
传统北澳大利亚原住民食品中的天然系列放射性核素
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:0
- 作者:
Paul Martin;G. Hancock;A. Johnston;A. Murray - 通讯作者:
A. Murray
Classification of spin-chain braid representations
自旋链编织表示法的分类
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Paul Martin;E. Rowell - 通讯作者:
E. Rowell
Phencyclidine (PCP) abuse. A close-up look at a growing problem.
苯环己哌啶 (PCP) 滥用。
- DOI:
10.1016/0030-4220(86)90171-4 - 发表时间:
1986 - 期刊:
- 影响因子:0
- 作者:
S. Isaacs;Paul Martin;James A. Washington - 通讯作者:
James A. Washington
Paul Martin的其他文献
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{{ truncateString('Paul Martin', 18)}}的其他基金
Investigating circadian regulation of wound repair in vivo and in vitro
研究体内和体外伤口修复的昼夜节律调节
- 批准号:
BB/W018594/1 - 财政年份:2022
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
Screening for, and characterisation of, novel immune cell extravasation genes in Drosophila, mice and man
果蝇、小鼠和人中新型免疫细胞外渗基因的筛选和表征
- 批准号:
MR/V011294/1 - 财政年份:2021
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
Statistical modelling of in vivo immune response dynamics in zebrafish to multiple stimuli
斑马鱼对多种刺激的体内免疫反应动态的统计模型
- 批准号:
BB/K018027/1 - 财政年份:2013
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
SBIR Phase I: Sensor for Hazardous Static Voltage
SBIR 第一阶段:危险静态电压传感器
- 批准号:
1314673 - 财政年份:2013
- 资助金额:
$ 74.3万 - 项目类别:
Standard Grant
Physical, algebraic and geometric underpinnings of topological quantum computation
拓扑量子计算的物理、代数和几何基础
- 批准号:
EP/I038683/1 - 财政年份:2012
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
Modeling of wound repair and inflammation in the Drosophila embryo
果蝇胚胎伤口修复和炎症的建模
- 批准号:
MR/J002577/1 - 财政年份:2012
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
SBIR Phase I: Electrochromic Nano-Pigment Dispersion
SBIR 第一阶段:电致变色纳米颜料分散体
- 批准号:
1012441 - 财政年份:2010
- 资助金额:
$ 74.3万 - 项目类别:
Standard Grant
Workshop: Themes at the interface of Physics and Algebraic Representation Theory
研讨会:物理与代数表示论界面的主题
- 批准号:
EP/E021328/1 - 财政年份:2006
- 资助金额:
$ 74.3万 - 项目类别:
Research Grant
NSF/CBMS Regional Conference in the Mathematical Sciences - "Numerical Methods in Forward and Inverse Electromagnetic Scattering" - June 3-7, 2002
NSF/CBMS 数学科学区域会议 - “正向和逆向电磁散射的数值方法” - 2002 年 6 月 3-7 日
- 批准号:
0121301 - 财政年份:2001
- 资助金额:
$ 74.3万 - 项目类别:
Standard Grant
Movements of Desert Plants in the Holocene: (Environmental Biology)
全新世沙漠植物的运动:(环境生物学)
- 批准号:
8214939 - 财政年份:1983
- 资助金额:
$ 74.3万 - 项目类别:
Standard Grant
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