Investigating the functions and therapeutic potential for Eph receptors and ephrins during wound repair and inflammation

研究 Eph 受体和肝配蛋白在伤口修复和炎症过程中的功能和治疗潜力

基本信息

  • 批准号:
    G0901822/1
  • 负责人:
  • 金额:
    $ 74.3万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2010
  • 资助国家:
    英国
  • 起止时间:
    2010 至 无数据
  • 项目状态:
    已结题

项目摘要

Wound healing is the body?s process of repairing damaged tissue and takes place for all wounds, be they a nick to the finger or the repair of internal organs after abdominal surgery. There are many occasions when tissue repair fails, leading to chronic non-healing wounds such as venous leg ulcers which are a huge clinical burden for elderly patients and suffered by about 500,000 people in the UK. Equally, the process can be too exuberant leading to fibrosis and scarring as a consequence of excessive contraction, healing and inflammation. In order to understand how tissue repair goes awry and how it might be improved, we need to better understand the process, and essentially that means figuring out how the dormant tissues of unwounded skin (or other organs), are awakened upon damage, allowing them to migrate and fill the gap created by the wound, and how they know when to stop when the wound is healed.The studies outlined here are to investigate a family of receptors and the proteins that bind to them, the Ephs and ephrins, that, despite being very well studied in embryonic development and in cancer and implicated in regulating the ?starting and stopping? of cell migrations in both these scenarios, have not previously been studied in the wound repair process. We have preliminary data in mouse that shows how several members of this large family of receptors become expressed and activated in particular cell types during the wound closure process, in ways that are suggestive of their being key players, and we will look to see whether the same is true in human wound tissues and whether biopsies from pathological wounds, in particular longstanding leg ulcers, have an altered pattern of these receptors. We will then test whether modulating particular Eph family members will allow us to alter and improve some aspects of healing while not affecting others, with a view to designing therapies that can either ?kickstart? the tissues of a non-healing wound to repair itself or shut down the repair machinery in a wound that is too inflamed and/or too exuberant and likely to form a bad scar.
伤口愈合是身体-S修复受损组织的过程,发生于所有的伤口,无论是手指的划痕还是腹部手术后内脏的修复。在许多情况下,组织修复失败会导致慢性无法愈合的伤口,如静脉性腿部溃疡,这是老年患者的巨大临床负担,在英国约有50万人遭受痛苦。同样,由于过度收缩、愈合和炎症,这一过程可能过于活跃,导致纤维化和疤痕形成。为了了解组织修复是如何出错以及如何改善的,我们需要更好地了解这一过程,本质上这意味着弄清楚未受损伤的皮肤(或其他器官)的休眠组织是如何在受损时被唤醒的,允许它们迁移并填补伤口造成的缺口,以及它们如何知道在伤口愈合时何时停止。这里概述的研究是调查一系列受体及其结合蛋白,Ephs和Ephins,尽管在胚胎发育和癌症中进行了很好的研究,并与调节启动和停止有关?在这两种情况下的细胞迁移,以前还没有在伤口修复过程中进行研究。我们在小鼠身上的初步数据显示,在伤口闭合过程中,这个受体大家族的几个成员如何在特定的细胞类型中表达和激活,这表明它们是关键参与者,我们将研究在人类伤口组织中是否如此,以及来自病理性伤口的活检组织,特别是长期的腿部溃疡,是否改变了这些受体的模式。然后我们将测试调节特定的Eph家庭成员是否允许我们在不影响其他方面的情况下改变和改善康复的某些方面,以期设计出既可以启动?未愈合伤口的组织,用于自我修复或关闭过于发炎和/或过于旺盛并可能形成严重疤痕的伤口的修复机械。

项目成果

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Paul Martin其他文献

Martin, Paul (2013) Embodiment in skateboarding videogames. International Journal of Performance Arts and Digital Media, 9 (2). pp. 315-327
Martin, Paul (2013) 滑板电子游戏的体现。
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Paul Martin
  • 通讯作者:
    Paul Martin
The influence of health concerns in scientific and policy debates on climate change
健康问题对气候变化科学和政策辩论的影响
Classification of spin-chain braid representations
自旋链编织表示法的分类
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Paul Martin;E. Rowell
  • 通讯作者:
    E. Rowell
On a canonical lift of Artin's representation to loop braid groups
论阿廷对循环辫子组表示的规范提升
  • DOI:
    10.1016/j.jpaa.2021.106760
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    C. Damiani;João F. Martins;Paul Martin
  • 通讯作者:
    Paul Martin
The Association of Electrocardiographic Abnormalities and Acute Coronary Syndrome in Emergency Patients With Chest Pain
急诊胸痛患者心电图异常与急性冠状动脉综合征的关系
  • DOI:
    10.1111/acem.13123
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    T. Knowlman;J. Greenslade;W. Parsonage;T. Hawkins;L. Ruane;Paul Martin;S. Prasad;D. Lancini;L. Cullen
  • 通讯作者:
    L. Cullen

Paul Martin的其他文献

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{{ truncateString('Paul Martin', 18)}}的其他基金

Investigating circadian regulation of wound repair in vivo and in vitro
研究体内和体外伤口修复的昼夜节律调节
  • 批准号:
    BB/W018594/1
  • 财政年份:
    2022
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
Screening for, and characterisation of, novel immune cell extravasation genes in Drosophila, mice and man
果蝇、小鼠和人中新型免疫细胞外渗基因的筛选和表征
  • 批准号:
    MR/V011294/1
  • 财政年份:
    2021
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
Statistical modelling of in vivo immune response dynamics in zebrafish to multiple stimuli
斑马鱼对多种刺激的体内免疫反应动态的统计模型
  • 批准号:
    BB/K018027/1
  • 财政年份:
    2013
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
SBIR Phase I: Sensor for Hazardous Static Voltage
SBIR 第一阶段:危险静态电压传感器
  • 批准号:
    1314673
  • 财政年份:
    2013
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Standard Grant
Physical, algebraic and geometric underpinnings of topological quantum computation
拓扑量子计算的物理、代数和几何基础
  • 批准号:
    EP/I038683/1
  • 财政年份:
    2012
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
Modeling of wound repair and inflammation in the Drosophila embryo
果蝇胚胎伤口修复和炎症的建模
  • 批准号:
    MR/J002577/1
  • 财政年份:
    2012
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
SBIR Phase I: Electrochromic Nano-Pigment Dispersion
SBIR 第一阶段:电致变色纳米颜料分散体
  • 批准号:
    1012441
  • 财政年份:
    2010
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Standard Grant
Workshop: Themes at the interface of Physics and Algebraic Representation Theory
研讨会:物理与代数表示论界面的主题
  • 批准号:
    EP/E021328/1
  • 财政年份:
    2006
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Research Grant
NSF/CBMS Regional Conference in the Mathematical Sciences - "Numerical Methods in Forward and Inverse Electromagnetic Scattering" - June 3-7, 2002
NSF/CBMS 数学科学区域会议 - “正向和逆向电磁散射的数值方法” - 2002 年 6 月 3-7 日
  • 批准号:
    0121301
  • 财政年份:
    2001
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Standard Grant
Movements of Desert Plants in the Holocene: (Environmental Biology)
全新世沙漠植物的运动:(环境生物学)
  • 批准号:
    8214939
  • 财政年份:
    1983
  • 资助金额:
    $ 74.3万
  • 项目类别:
    Standard Grant

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数学物理中精确可解模型的代数方法
  • 批准号:
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