Diagnostic markers of clinical allergy versus sensitisation to peanut

花生临床过敏与致敏的诊断标志物

• 批准号: G0902018/1
• 负责人: Alexandra Santos
• 金额: $ 30.08万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902018%2F1
• 关键词: Diagnostic; markers; clinical; allergy; versus

Peanut allergy (PA) is particularly problematic since it is increasingly common in infants andchildren, may be life-threatening, frequently persists through adulthood and has a significant impacton children?s quality of life.The diagnosis of PA is based on a combination of a history of allergic reaction(s) to peanut andpositive allergy tests. However, this is not reliable because many patients have positive allergy testsand tolerate peanut whilst others have positive allergy tests and are peanut allergic. The only way toclarify this is by giving the child peanuts in oral food challenges (OFC). However, OFC are expensive,laborious and potentially dangerous, as they may induce allergic reactions.Our proposed research project aims to provide fundamental insights into the mechanisms ofallergy and tolerance and also to distinguish between peanut allergic children and those who havepositive allergy tests but tolerate peanut without the need for OFC.This project will improve allergy diagnosis, allowing for a more accurate distinction of allergicchildren among children with positive allergy tests, not only to peanut but also to other allergens. Byunderstanding why some children with positive allergy tests react and others do not, we maydevelop new definitive treatments for PA

花生过敏 (PA) 是一个特别成问题的问题，因为它在婴儿和儿童中越来越常见，可能危及生命，经常持续到成年期，并对儿童的生活质量产生重大影响。PA 的诊断基于花生过敏反应史和过敏测试阳性。然而，这是不可靠的，因为许多患者的过敏测试呈阳性并且对花生耐受，而其他患者的过敏测试呈阳性并且对花生过敏。澄清这一点的唯一方法是在口服食物挑战（OFC）中给孩子吃花生。然而，OFC 昂贵、费力且具有潜在危险，因为它们可能会引起过敏反应。我们提出的研究项目旨在提供对过敏和耐受机制的基本见解，并区分花生过敏儿童和那些过敏测试呈阳性但无需 OFC 即可耐受花生的儿童。该项目将改善过敏诊断，从而更准确地区分花生过敏儿童。 过敏儿童 过敏测试呈阳性的儿童，不仅对花生，而且对其他过敏原。通过了解为什么一些过敏测试呈阳性的儿童有反应而其他儿童则没有反应，我们可以开发新的针对 PA 的明确治疗方法