Assessing methods to specify the targeted difference for a randomised controlled trial
评估指定随机对照试验目标差异的方法
基本信息
- 批准号:G0902147/1
- 负责人:
- 金额:$ 19.48万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2010
- 资助国家:英国
- 起止时间:2010 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Increasingly it is acknowledged that decisions about what health care to provide should be evidence based. One part of the evidence needed is whether the intervention is a beneficial and worthwhile use of the limited money available to provide health care. Arguably the best way of providing this evidence is by conducting a randomised controlled trial. In a randomised controlled trial individuals, or groups of individuals, are typically randomly assigned to receive either the new treatment (which might be the way in which care is provided) or an alternative treatment. A sufficient number of people is needed so that we can be confident that if a difference between treatments exists we can detect it. The size of difference between the two treatments desired to be identified (the target difference) affects the number of people needed to be recruited and the cost of the study. If the target difference is not correctly identified then there is a chance that time, effort (by patients, health care practitioners and researchers) and money will be wasted or poorly used. It is also possible that the health of patients may be adverse affected because the target difference was too small and we carry on randomising people to a treatment that we should already be able to say is inferior. Alternatively, if the target is too large we may fail to detect a truly important difference and as a result delay or prevent the introduction of a worthwhile treatment.In this study we will systematically identify methods of determining the target difference. Scientific papers will be identified that described different methods, experts in the field will be approached, and we will survey organisations and individuals who are actively involved in the design and conduct of randomised controlled tiles. The different methods that we identify will be described, strengths and weaknesses appraised and potential scope for their use assessed. We will develop draft guidance for researchers and funders of randomised clinical trials. This will include separate sections for different types of trials and on different ways in which the outcomes of a treatment might be measured. This guidance will first be discussed amongst the study applicants and an expert advisory group. The recommendations will then presented at a symposium to which those with an interest in the design and conduct of trials and will help further refine recommendations and act as a first method of dissemination.
人们越来越认识到,关于提供什么样的医疗保健的决定应该基于证据。所需证据的一部分是,干预是否是对提供医疗保健的有限资金的有益和值得的使用。可以说,提供这一证据的最佳方法是进行随机对照试验。在随机对照试验中,个体或个体组通常被随机分配接受新治疗(可能是提供护理的方式)或替代治疗。需要有足够数量的研究对象,这样我们才能确信,如果两种治疗方法之间存在差异,我们可以检测到它。需要确定的两种治疗方法之间差异的大小(目标差异)会影响需要招募的人数和研究成本。如果目标差异没有被正确识别,那么时间、精力(患者、医疗保健从业者和研究人员)和金钱就有可能被浪费或利用不当。患者的健康也可能受到不利影响,因为目标差异太小,我们继续将人们随机分配到我们应该已经能够说是劣效的治疗。或者,如果目标太大,我们可能无法检测到一个真正重要的差异,因此延迟或阻止引入一个有价值的treatment.In这项研究中,我们将系统地确定方法的目标差异。将确定描述不同方法的科学论文,将与该领域的专家联系,我们将调查积极参与随机控制瓷砖设计和实施的组织和个人。我们确定的不同方法将被描述,优点和缺点的评价和潜在的使用范围进行评估。我们将为随机临床试验的研究人员和资助者制定指南草案。这将包括不同类型试验的单独章节,以及衡量治疗结果的不同方法。本指南将首先在研究申请人和专家咨询小组之间进行讨论。这些建议随后将在一次专题讨论会上提出,对试验的设计和进行感兴趣的人将在会上发言,这将有助于进一步完善建议,并作为第一个传播方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan Cook其他文献
Describing the landscape of nutrition- and diet-related randomized controlled trials: metaresearch study of protocols published between 2012 and 2022
描述营养与饮食相关随机对照试验的格局:对2012年至2022年间发表的试验方案的元研究
- DOI:
10.1016/j.ajcnut.2025.01.016 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:6.900
- 作者:
Flávia Moraes Silva;Amanda Rodrigues Amorim Adegboye;Celeste Naude;Cintia Curioni;Fabio S Gomes;Gary S Collins;Gilberto Kac;Jennifer Anne de Beyer;Jonathan Cook;Leila Cheikh Ismail;Matthew J Page;Neha Khandpur;Sallie Lamb;Sally Hopewell;Shaima Saleh;Shona Kirtley;Simone Bernardes;Solange Durão;Colby J Vorland;Michael Maia Schlussel - 通讯作者:
Michael Maia Schlussel
Invited Discussion on: The Effect of Hyaluronidase on Depth of Necrosis in Hyaluronic Acid Filling-Related Skin Complications
- DOI:
10.1007/s00266-020-01796-x - 发表时间:
2020-06-04 - 期刊:
- 影响因子:2.800
- 作者:
Jonathan Cook;Jason N. Pozner - 通讯作者:
Jason N. Pozner
Invited Discussion on: A Prospective Study Determining Patient Satisfaction with Combined Cryolipolysis and Shockwave Therapy Treatment for Non-Invasive Body Contouring
- DOI:
10.1007/s00266-021-02239-x - 发表时间:
2021-03-25 - 期刊:
- 影响因子:2.800
- 作者:
Jonathan Cook;Jason N. Pozner - 通讯作者:
Jason N. Pozner
Developing a patient and public involvement intervention to enhance recruitment and retention in surgical trials (PIRRIST): study protocol
- DOI:
10.1186/1745-6215-16-s2-p89 - 发表时间:
2015-11-16 - 期刊:
- 影响因子:2.000
- 作者:
Joanna Crocker;Sian Rees;Louise Locock;Sophie Petit-Zeman;Alan Chant;Shaun Treweek;Jonathan Cook;Nicola Farrar;Kerry Woolfall;Richard Bulbulia - 通讯作者:
Richard Bulbulia
Difficulties with defining diagnostic accuracy study outcomes
- DOI:
10.1186/1745-6215-16-s2-p49 - 发表时间:
2015-11-16 - 期刊:
- 影响因子:2.000
- 作者:
Katie Banister;Craig Ramsay;Jonathan Cook;Charles Boachie;Augusto Azuara-Blanco - 通讯作者:
Augusto Azuara-Blanco
Jonathan Cook的其他文献
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{{ truncateString('Jonathan Cook', 18)}}的其他基金
Collaborative Research:Beyond Representation: Adversity Experiences on STEM Motivation, Performance, and Persistence
合作研究:超越表征:逆境经历对 STEM 动机、表现和毅力的影响
- 批准号:
2100283 - 财政年份:2021
- 资助金额:
$ 19.48万 - 项目类别:
Standard Grant
Reducing Attrition in STEM Doctoral Education: A Longitudinal Investigation using Momentary Assessment and Social Psychological Intervention
减少 STEM 博士教育中的人员流失:利用瞬时评估和社会心理干预进行的纵向调查
- 批准号:
1661214 - 财政年份:2017
- 资助金额:
$ 19.48万 - 项目类别:
Continuing Grant
Methodology State-of-the-art workshop: Choosing the target difference (“effect size”) for a randomised controlled trial
最先进的方法论研讨会:为随机对照试验选择目标差异(“效应大小”)
- 批准号:
MC_PC_16101 - 财政年份:2016
- 资助金额:
$ 19.48万 - 项目类别:
Intramural
Evaluating the role of expertise-based trial designs in trials of surgical interventions
评估基于专业知识的试验设计在手术干预试验中的作用
- 批准号:
G1002292/2 - 财政年份:2013
- 资助金额:
$ 19.48万 - 项目类别:
Fellowship
MRI: Acquisition of an Instrument for Research in Irregularly Parallel Big Data Computation
MRI:购买用于不规则并行大数据计算研究的仪器
- 批准号:
1337884 - 财政年份:2013
- 资助金额:
$ 19.48万 - 项目类别:
Standard Grant
Evaluating the role of expertise-based trial designs in trials of surgical interventions
评估基于专业知识的试验设计在手术干预试验中的作用
- 批准号:
G1002292/1 - 财政年份:2011
- 资助金额:
$ 19.48万 - 项目类别:
Fellowship
Statistical methods for randomised surgical trials
随机手术试验的统计方法
- 批准号:
G0601938/1 - 财政年份:2007
- 资助金额:
$ 19.48万 - 项目类别:
Fellowship
CRI: Infrastructure for Networked Sensor Information Technology
CRI:网络传感器信息技术基础设施
- 批准号:
0551734 - 财政年份:2006
- 资助金额:
$ 19.48万 - 项目类别:
Standard Grant
Collaborative Research: Software and Hardware Support for Efficient Monitoring of Program Behavior
协作研究:高效监控程序行为的软硬件支持
- 批准号:
0541075 - 财政年份:2006
- 资助金额:
$ 19.48万 - 项目类别:
Standard Grant
Active Support for the Evolution of Component-Based Software
积极支持基于组件的软件的发展
- 批准号:
0306457 - 财政年份:2003
- 资助金额:
$ 19.48万 - 项目类别:
Continuing Grant
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