Investigating the neurophysiological basis of circuit-specific laminar rs-fMRI
研究电路特异性层流 rs-fMRI 的神经生理学基础
基本信息
- 批准号:10518479
- 负责人:
- 金额:$ 214.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAnestheticsAnimalsAstrocytesAxonBilateralBiological MarkersBlood VesselsBrainBrain DiseasesBrain InjuriesBrain MappingCerebrovascular DisordersCerebrovascular systemCerebrumChronicClinicalCorpus CallosumCoupledCouplingDiagnosticDiseaseEtiologyFiberFoundationsFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderGoalsHypotensionImpairmentInjuryLesionMeasuresMediatingMethodsMusNetwork-basedNeuronsPathologicPatientsPatternPhotometryPlayRegulationResolutionRestRoleScanningSchemeSignal TransductionSourceSpecific qualifier valueSpecificityTechniquesTestingTo specifyTranslatingVascular DementiaVascular DiseasesWorkawakebasebioimagingblood oxygen level dependentcerebrovasculardiagnostic toolfunctional disabilityhypoperfusionimaging biomarkerimprovedmouse modelmultimodalitynervous system disorderneurophysiologyneuroregulationneurovascularneurovascular couplingnoveloptogeneticspotential biomarkerresponsetoolvascular cognitive impairment and dementiawhite matterwhite matter injury
项目摘要
Resting-state fMRI has emerged as a potential method to identify diagnostic bio-imaging markers of a broad
spectrum of neurological disorders by measuring the low-frequency fluctuation (LFF) correlation features of
diseased brains. Due to the fMRI signal’s indirect coupling to neuronal activity, a fundamental challenge of rs-
fMRI mapping is how to extract the true “functional connectivity” feature across cortices with circuit specificity.
Both direct corticocortical connections, e.g. callosal projections, and subcortical neuromodulatory projections
can modulate rs-fMRI connectivity with converging effects on neuro-glio-vascular (NGV) interactions. Also, au-
tonomic regulation on gliovascular dynamics further confounds rs-fMRI LFF when interpreting the brain dam-
age with vascular impairment in various cerebrovascular diseases. We propose to implement line-scanning
and single-vessel fMRI methods in a multi-modal platform to dissect laminar and vascular-specific rs-fMRI LFF
and decipher NGV signaling underlying rs-fMRI LFF. Here, we will focus on elucidating the transcallosal circuit-
based interhemispheric rs-fMRI LFF correlation in the normal and diseased mouse model with hypoperfusion-
induced cerebrovascular white matter injury in the corpus callosum. Three aims will be addressed: 1). We will
investigate the causal linkage between laminar-specific bilateral LFF and transcallosal projection. Two hypoth-
eses will be tested: i). Layer-specific transcallosal projections determine bilateral LFF laminar correlation pat-
terns, and ii). Callosal-driven laminar LFF holds distinct oscillation features from brain state-dependent global
LFF. 2). We will differentiate the NGV signaling of callosal-specific and global vascular LFF using multi-modal
fMRI. Also, we will test two hypotheses: i). Callosal projection neuron-specific oscillation mediates circuit-spe-
cific bilateral LFF, and ii). Distinct astrocytic Ca2+ signals coupled to either callosal projection neuronal activity
or global neuromodulation contribute to different forms of LFF correlation. 3). We will specify callosal-specific
and global vascular LFF in the hypoperfusion-induced white matter injury mouse model. We will test if hy-
poperfusion-induced cerebral flow changes alter global vascular LFF and hypoperfusion-induced injury in the
corpus callosum leads to altered bilateral rs-fMRI connectivity. This proposal aims to reveal the mechanistic
NGV regulation of circuit-specific rs-fMRI LFF and apply novel rs-fMRI methods in the diseased mouse model
to set the foundation to translate specific LFF correlation patterns as potential biomarkers of circuit dysfunction
or vascular impairment in pathological brains.
静息状态功能磁共振成像已成为一种潜在的方法,以确定诊断生物成像标志物的广泛
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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EMERY N BROWN其他文献
EMERY N BROWN的其他文献
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{{ truncateString('EMERY N BROWN', 18)}}的其他基金
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
- 批准号:
10610946 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
- 批准号:
10445654 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Project 1: Human Studies of Anesthetic Action
项目 1:麻醉作用的人体研究
- 批准号:
10093071 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
- 批准号:
10093061 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
- 批准号:
9209574 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
全身麻醉下老化的大脑:神经生理学、衰老和阿尔茨海默病的神经影像生物标志物以及术后认知结果
- 批准号:
9904463 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
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