Investigating the neurophysiological basis of circuit-specific laminar rs-fMRI
研究电路特异性层流 rs-fMRI 的神经生理学基础
基本信息
- 批准号:10518479
- 负责人:
- 金额:$ 214.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAnestheticsAnimalsAstrocytesAxonBilateralBiological MarkersBlood VesselsBrainBrain DiseasesBrain InjuriesBrain MappingCerebrovascular DisordersCerebrovascular systemCerebrumChronicClinicalCorpus CallosumCoupledCouplingDiagnosticDiseaseEtiologyFiberFoundationsFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderGoalsHypotensionImpairmentInjuryLesionMeasuresMediatingMethodsMusNetwork-basedNeuronsPathologicPatientsPatternPhotometryPlayRegulationResolutionRestRoleScanningSchemeSignal TransductionSourceSpecific qualifier valueSpecificityTechniquesTestingTo specifyTranslatingVascular DementiaVascular DiseasesWorkawakebasebioimagingblood oxygen level dependentcerebrovasculardiagnostic toolfunctional disabilityhypoperfusionimaging biomarkerimprovedmouse modelmultimodalitynervous system disorderneurophysiologyneuroregulationneurovascularneurovascular couplingnoveloptogeneticspotential biomarkerresponsetoolvascular cognitive impairment and dementiawhite matterwhite matter injury
项目摘要
Resting-state fMRI has emerged as a potential method to identify diagnostic bio-imaging markers of a broad
spectrum of neurological disorders by measuring the low-frequency fluctuation (LFF) correlation features of
diseased brains. Due to the fMRI signal’s indirect coupling to neuronal activity, a fundamental challenge of rs-
fMRI mapping is how to extract the true “functional connectivity” feature across cortices with circuit specificity.
Both direct corticocortical connections, e.g. callosal projections, and subcortical neuromodulatory projections
can modulate rs-fMRI connectivity with converging effects on neuro-glio-vascular (NGV) interactions. Also, au-
tonomic regulation on gliovascular dynamics further confounds rs-fMRI LFF when interpreting the brain dam-
age with vascular impairment in various cerebrovascular diseases. We propose to implement line-scanning
and single-vessel fMRI methods in a multi-modal platform to dissect laminar and vascular-specific rs-fMRI LFF
and decipher NGV signaling underlying rs-fMRI LFF. Here, we will focus on elucidating the transcallosal circuit-
based interhemispheric rs-fMRI LFF correlation in the normal and diseased mouse model with hypoperfusion-
induced cerebrovascular white matter injury in the corpus callosum. Three aims will be addressed: 1). We will
investigate the causal linkage between laminar-specific bilateral LFF and transcallosal projection. Two hypoth-
eses will be tested: i). Layer-specific transcallosal projections determine bilateral LFF laminar correlation pat-
terns, and ii). Callosal-driven laminar LFF holds distinct oscillation features from brain state-dependent global
LFF. 2). We will differentiate the NGV signaling of callosal-specific and global vascular LFF using multi-modal
fMRI. Also, we will test two hypotheses: i). Callosal projection neuron-specific oscillation mediates circuit-spe-
cific bilateral LFF, and ii). Distinct astrocytic Ca2+ signals coupled to either callosal projection neuronal activity
or global neuromodulation contribute to different forms of LFF correlation. 3). We will specify callosal-specific
and global vascular LFF in the hypoperfusion-induced white matter injury mouse model. We will test if hy-
poperfusion-induced cerebral flow changes alter global vascular LFF and hypoperfusion-induced injury in the
corpus callosum leads to altered bilateral rs-fMRI connectivity. This proposal aims to reveal the mechanistic
NGV regulation of circuit-specific rs-fMRI LFF and apply novel rs-fMRI methods in the diseased mouse model
to set the foundation to translate specific LFF correlation patterns as potential biomarkers of circuit dysfunction
or vascular impairment in pathological brains.
静息状态功能磁共振成像已成为一种潜在的方法,以确定诊断生物成像标记物的广泛
通过测量神经系统疾病的低频波动(LFF)相关特征,
病态的大脑由于fMRI信号与神经元活动的间接耦合,rs-
功能磁共振成像映射是如何提取真正的“功能连接”的特点,跨皮层与电路的特异性。
直接的皮质-皮质连接,如胼胝体投射和皮质下神经调节投射
可以调节rs-fMRI连接,对神经胶质血管(NGV)相互作用具有会聚效应。还有,Au-
神经系统对神经胶质血管动力学的调节在解释脑屏障时进一步混淆了rs-fMRI LFF,
各种脑血管疾病的血管损害年龄。我们建议实施行扫描
和单血管功能磁共振成像方法在多模式平台解剖层和血管特异性rs-fMRI LFF
并破译rs-fMRI LFF下的NGV信号。在这里,我们将重点阐述跨胼胝体回路-
基于大脑半球间rs-fMRI LFF相关性的正常和低灌注患病小鼠模型,
诱发脑血管胼胝体白色物质损伤。三个目标将被解决:1)。我们将
研究椎板特异性双侧LFF和经胼胝体投射之间的因果关系。两个假设-
将测试环境、社会和经济状况:i)。层特异性经胼胝体投影确定双侧LFF层相关模式
,和ii)。胼胝体驱动的层流LFF具有与大脑状态依赖的全局LFF不同的振荡特征。
LFF。2)。我们将使用多模态分析来区分胼胝体特异性和全局血管LFF的NGV信号传导。
功能磁共振成像。此外,我们将测试两个假设:i)。胼胝体投射神经元特异性振荡介导的回路-spe-
cific bilateral LFF,和ii).不同的星形胶质细胞Ca 2+信号与胼胝体投射神经元活动耦合
或整体神经调节有助于不同形式的LFF相关性。3)。我们将指定胼胝体特异性
和低灌注诱导的白色物质损伤小鼠模型中的全局血管LFF。我们将测试是否-
灌注后诱导的脑血流变化改变了脑缺血再灌注大鼠的整体血管LFF和低灌注诱导的损伤。
胼胝体导致双侧rs-fMRI连接改变。该提案旨在揭示
NGV对电路特异性rs-fMRI LFF的调控及rs-fMRI新方法在疾病小鼠模型中的应用
为将特定LFF相关模式转化为回路功能障碍的潜在生物标志物奠定基础
或病理性脑血管损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
EMERY N BROWN其他文献
EMERY N BROWN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('EMERY N BROWN', 18)}}的其他基金
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
- 批准号:
10610946 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
- 批准号:
10445654 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Project 1: Human Studies of Anesthetic Action
项目 1:麻醉作用的人体研究
- 批准号:
10093071 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
- 批准号:
10093061 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
- 批准号:
9209574 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
全身麻醉下老化的大脑:神经生理学、衰老和阿尔茨海默病的神经影像生物标志物以及术后认知结果
- 批准号:
9904463 - 财政年份:2017
- 资助金额:
$ 214.12万 - 项目类别:
相似海外基金
Investigation of the mechanism of recovery effect of anesthetics on endothelial glycocalyx damage
麻醉药对内皮糖萼损伤恢复作用的机制探讨
- 批准号:
23K08341 - 财政年份:2023
- 资助金额:
$ 214.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of a Novel Functional Mechanism of Intravenous Anesthetics Based on the Membrane Lipid Theory and Its Application to Clinical Practice
基于膜脂理论的静脉麻醉药新作用机制的阐明及其在临床实践中的应用
- 批准号:
23K06361 - 财政年份:2023
- 资助金额:
$ 214.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Disruptions in the brain reward system through postnatal exposure to GABA agonists and anesthetics
产后接触 GABA 激动剂和麻醉剂会扰乱大脑奖励系统
- 批准号:
10657509 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Electrophysiological analysis of proarrhythmic properties of volatile anesthetics using an originally developed arrhythmogenic model
使用最初开发的致心律失常模型对挥发性麻醉药的致心律失常特性进行电生理分析
- 批准号:
22K09032 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Modification of the intercellular network of immune cells in tumor microenvironment by sedatives and anesthetics.
通过镇静剂和麻醉剂改变肿瘤微环境中免疫细胞的细胞间网络。
- 批准号:
22K09083 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The role of astrocytes in emergence from volatile anesthetics
星形胶质细胞在挥发性麻醉剂苏醒中的作用
- 批准号:
10340339 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Disruptions in the brain reward system through postnatal exposure to GABA agonists and anesthetics
产后接触 GABA 激动剂和麻醉剂会扰乱大脑奖励系统
- 批准号:
10440005 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Mechanisms and blood-based biomarkers of intergenerational neurobehavioral effects of general anesthetics
全身麻醉药代际神经行为效应的机制和血液生物标志物
- 批准号:
10538703 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
对麻醉药的神经生理学抵抗力低是临床前/前驱阿尔茨海默病和神经血管病理学、谵妄风险和注意力不集中的标志
- 批准号:
10870632 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别:
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
对麻醉药的神经生理学抵抗力低是临床前/前驱阿尔茨海默病和神经血管病理学、谵妄风险和注意力不集中的标志
- 批准号:
10671023 - 财政年份:2022
- 资助金额:
$ 214.12万 - 项目类别: