The safety of glucocorticoids in patients with inflammatory musculoskeletal conditions

糖皮质激素在炎症性肌肉骨骼疾病患者中的安全性

• 批准号: G0902272/1
• 负责人: William Dixon
• 金额: $ 138.13万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902272%2F1
• 关键词: safety; glucocorticoids; patients; inflammatory; musculoskeletal

Glucocorticoids, also known as steroids, are drugs commonly used for the treatment of rheumatoid arthritis and other inflammatory conditions. Steroids are a good treatment because they quickly ease joint pain, swelling and stiffness, thus improving disability. However, as with most medication, there are potential side effects. When starting medication, most patients want to know their chance of developing side effects. However, we don‘t know accurately how commonly side effects occur, what dose of steroid leads to side effects, or what sort of person is particularly at risk. The chance of side effects probably varies according to many factors, including how old a patient is, their gender, whether they have other diseases, or are taking other medication. This research aims to answer these questions, and to provide a likelihood of side effects tailored to the individual.Only patients themselves know whether they take their medicines, at what dose, or whether they develop side effects. In order to improve risk measurement, we need to collect such information directly from patients. Then, having measured risk, we need to improve the way we communicate this information to patients. This project aims to develop electronic systems to advance this two-way communication.

糖皮质激素，也称为类固醇，是常用于治疗类风湿性关节炎和其他炎症性疾病的药物。类固醇是一种很好的治疗方法，因为它们可以快速缓解关节疼痛、肿胀和僵硬，从而改善残疾。然而，与大多数药物一样，存在潜在的副作用。当开始用药时，大多数患者想知道出现副作用的机会。然而，我们并不准确地知道副作用发生的频率、多少剂量的类固醇会导致副作用，或者什么样的人特别有风险。出现副作用的可能性可能因多种因素而异，包括患者的年龄、性别、是否患有其他疾病或正在服用其他药物。这项研究旨在回答这些问题，并提供针对个体的副作用的可能性。只有患者自己知道他们是否服用药物、剂量是多少，或者是否会出现副作用。为了改进风险测量，我们需要直接从患者那里收集此类信息。然后，在测量风险后，我们需要改进向患者传达此信息的方式。该项目旨在开发电子系统来推进这种双向通信。