Clinical and Immunological Evaluation of T cell- and Antibody-Inducing Viral Vector Vaccines against Blood-Stage Malar

针对血期颧骨的 T 细胞和抗体诱导病毒载体疫苗的临床和免疫学评价

• 批准号: G1000527/1
• 负责人: Simon Draper
• 金额: $ 140.75万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000527%2F1
• 关键词: Clinical; Immunological; Evaluation; cell; Antibody

Malaria remains a huge public health problem in the developing world. The development of an effective vaccine remains an important but elusive goal. Malaria is caused by a parasite that first infects the liver before moving into the blood where it causes disease. A few vaccines have been developed recently that can kill some parasites in the liver, however, there is still no vaccine that can kill parasites in the blood.This research will test a new vaccine technology against the parasites in the blood. These vaccines, developed by scientists at the Jenner Institute, Oxford University, use viruses that are genetically engineered to look like malaria parasites. The work will test the safety and effectiveness of these vaccines in volunteers in clinical trials in Oxford, and importantly also study the immune responses produced by them. Scientists can then attempt to figure out which immune responses are killing the parasites. This research will also assess how malaria infection can interfere with immune responses in humans in both the UK and Africa. It is extremely important to understand these interactions between malaria parasites and the human immune system, because we can use this information to help design better vaccines in the future.

在发展中国家，疟疾仍然是一个巨大的公共卫生问题。开发有效的疫苗仍然是一个重要但难以实现的目标。疟疾是由一种寄生虫引起的，这种寄生虫首先感染肝脏，然后进入血液，在血液中致病。最近已经开发出一些疫苗可以杀死肝脏中的一些寄生虫，但仍然没有疫苗可以杀死血液中的寄生虫。这项研究将测试一种针对血液中寄生虫的新疫苗技术。这些疫苗由牛津大学詹纳研究所的科学家开发，使用的病毒经过基因工程，看起来像疟疾寄生虫。这项工作将在牛津的临床试验中在志愿者身上测试这些疫苗的安全性和有效性，重要的是还将研究它们产生的免疫反应。然后，科学家可以尝试找出是哪种免疫反应杀死了寄生虫。这项研究还将评估疟疾感染如何干扰英国和非洲人类的免疫反应。了解疟疾寄生虫和人类免疫系统之间的这些相互作用是极其重要的，因为我们可以利用这些信息来帮助未来设计更好的疫苗。