A. Olotu, Ifakara Health Institute - Immune responses in malaria-exposed children immunised with a new generation blood-stage malaria vaccine.

A. Olotu，伊法卡拉健康研究所 - 接种新一代血期疟疾疫苗的疟疾暴露儿童的免疫反应。

• 批准号: MR/P020593/1
• 负责人: Simon Draper
• 金额: $ 78.68万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP020593%2F1
• 关键词: A.; Olotu; Ifakara; Health; Institute

Scientists have discovered a protein called Pf reticulocyte-binding protein homolog 5 (PfRH5) which has shown promising results as a candidate malaria vaccine in studies conducted in monkeys and humans living in areas where there is no malaria. The safety and the ability of this vaccine to produce protective antibody responses in adults, young children and infants residing in areas with malaria is unknown. The ARL candidate will conduct a clinical trial and use standard laboratory techniques to determine if this vaccine is safe and well-tolerated in adults, young children and infants and to find out if it can produce antibodies capable of killing parasites growing in red blood cells in laboratory tests. The study will recruit volunteers residing in a low malaria transmission area in Bagamoyo, Tanzania. The study will provide new knowledge with regard to the potential for PfRH5 protein to be included in a malaria vaccine and inform decisions to conduct larger field trials to evaluate efficacy. The results will also identify whether there is scope to further improve this vaccine before conducting bigger trials in the field.

科学家们发现了一种名为Pf网织红细胞结合蛋白同系物5（PfRH5）的蛋白质，该蛋白质在生活在没有疟疾的地区的猴子和人类中进行的研究中显示出作为候选疟疾疫苗的有希望的结果。这种疫苗在居住在疟疾地区的成人、幼儿和婴儿中产生保护性抗体反应的安全性和能力尚不清楚。ARL候选人将进行临床试验，并使用标准的实验室技术来确定这种疫苗在成人，幼儿和婴儿中是否安全和耐受性良好，并确定它是否可以产生能够杀死红细胞中寄生虫的抗体。这项研究将招募居住在坦桑尼亚巴加莫约疟疾低传播区的志愿者。该研究将提供有关PfRH5蛋白被纳入疟疾疫苗的潜力的新知识，并为进行更大规模的田间试验以评估疗效的决定提供信息。研究结果还将确定在该领域进行更大规模的试验之前，是否有进一步改进这种疫苗的余地。

项目成果

Understanding the role of serological and clinical data on assessing the dynamic of malaria transmission: a case study of Bagamoyo district, Tanzania.

• DOI: 10.11604/pamj.2022.43.60.35779
• 发表时间: 2022
• 期刊: The Pan African medical journal

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies.

• DOI: 10.1186/s12936-023-04591-6
• 发表时间: 2023-05-19
• 期刊: MALARIA JOURNAL
• 影响因子: 3
• 作者: Miura, Kazutoyo;Diouf, Ababacar;Fay, Michael P.;Barrett, Jordan R.;Payne, Ruth O.;Olotu, Ally I.;Minassian, Angela M.;Silk, Sarah E.;Draper, Simon J.;Long, Carole A.
• 通讯作者: Long, Carole A.