Mechanisms underlying limb regeneration in an adult vertebrate

成年脊椎动物肢体再生的机制

• 批准号: G1000870-E01/1
• 负责人: Jeremy Brockes
• 金额: $ 252.8万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000870-E01%2F1
• 关键词: Mechanisms; underlying; limb; regeneration; adult

Adult salamanders such as the newt are able to regenerate their limbs with complete recovery of function. How does a salamander regenerate its limb and why can we not do this? Our research is studying some of the critical components that underly limb regeneration, and in particular the ones that are found in salamanders and not in us. The salamander and human genome projects provide important resources for identifying such components. If we understood how they worked this would provide a new impetus for trying to enhance our own abilities to regenerate.

成年蝾螈，如蝾螈，能够再生四肢，功能完全恢复。蝾螈是如何再生肢体的，为什么我们不能这样做？我们的研究正在研究肢体再生的一些关键成分，特别是那些在蝾螈身上发现而在我们身上没有的成分。蝾螈和人类基因组计划为确定这些成分提供了重要的资源。如果我们了解了它们是如何工作的，这将为努力提高我们自己的再生能力提供新的动力。