Molecular mechanisms in urodele amphibian regeneration

有尾目两栖动物再生的分子机制

• 批准号: MR/J500008/1
• 负责人: Jeremy Brockes
• 金额: $ 97.67万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ500008%2F1
• 关键词: Molecular; mechanisms; urodele; amphibian; regeneration

Adult salamanders such as the newt are able to regenerate their limbs with complete recovery of function. How does a salamander regenerate its limb and why can we not do this? Our research is studying some of the critical components that underly limb regeneration, and in particular the ones that are found in salamanders and not in us. The salamander and human genome projects provide important resources for identifying such components. If we understood how they worked this would provide a new impetus for trying to enhance our own abilities to regenerate.

像蝾螈这样的成年蝾螈能够再生四肢，完全恢复功能。蝾螈是如何再生肢体的，为什么我们不能这么做？我们的研究是研究肢体再生的一些关键成分，特别是那些在蝾螈身上发现而不是在我们身上发现的成分。蝾螈和人类基因组计划为鉴定这些成分提供了重要的资源。如果我们了解它们是如何工作的，这将为尝试提高我们自己的再生能力提供新的动力。