Positional identity of adult stem cells during limb regeneration

成体干细胞在肢体再生过程中的位置同一性

• 批准号: G0600229/1
• 负责人: Jeremy Brockes
• 金额: $ 131.9万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600229%2F1
• 关键词: Positional; identity; adult; stem; cells

The ability to regenerate the adult limb is present in salamanders like the newt, and it has now become a long term goal for regenerative medicine in humans. Regeneration in a newt always gives rise just to the structures that were removed by amputation. Amputation at the wrist gives a hand, while amputation at the shoulder gives an entire arm. Regeneration proceeds from special stem cells which arise at the end of the stump. If we understood the difference between wrist level and shoulder level cells in a salamander, we would be in a much stronger position to engineer appropriate regeneration in man. The aim of our research is to understand what this difference is, and how it works in a salamander to control how much of the limb is regenerated.

再生成年肢体的能力存在于像蝾螈这样的火蜥蜴身上，这现在已经成为人类再生医学的长期目标。蝾螈的再生总是只产生那些被截肢移除的结构。手腕截肢给人一只手，而肩部截肢给人一整只胳膊。再生来自树桩末端长出的特殊干细胞。如果我们了解火蜥蜴的腕部和肩部细胞之间的区别，我们就能更好地在人类体内设计适当的再生。我们研究的目的是了解这种差异是什么，以及它是如何在火蜥蜴体内控制肢体再生的。