Positional identity of adult stem cells during limb regeneration

蝾螈等蝾螈具有再生成年肢体的能力，现在这已经成为人类再生医学的一个长期目标。蝾螈的再生总是只产生被截肢切除的结构。腕部截肢可以得到一只手，而肩部截肢可以得到整个手臂。再生来自残肢末端产生的特殊干细胞。如果我们了解了蝾螈腕部和肩部细胞之间的差异，我们就能更有力地在人类身上设计适当的再生。我们研究的目的是了解这种差异是什么，以及它是如何在蝾螈身上起作用的，以控制肢体的再生程度。

The ability to regenerate the adult limb is present in salamanders like the newt, and it has now become a long term goal for regenerative medicine in humans. Regeneration in a newt always gives rise just to the structures that were removed by amputation. Amputation at the wrist gives a hand, while amputation at the shoulder gives an entire arm. Regeneration proceeds from special stem cells which arise at the end of the stump. If we understood the difference between wrist level and shoulder level cells in a salamander, we would be in a much stronger position to engineer appropriate regeneration in man. The aim of our research is to understand what this difference is, and how it works in a salamander to control how much of the limb is regenerated.