ETHANOL AND ITS METABOLITES DURING INTOXICATION AND PHYSICAL DEPENDENCE

血液醋酸盐清除曲线呈双相特征， 乙醇依赖大鼠的乙醇戒断期。 血醋酸盐 浓度保持相对稳定15至20小时，在此期间， 时间以直线方式除去血液乙醇。 血醋酸盐 浓度保持在约8至9 mg/dL的平台上。 当 血液乙醇浓度降低至约80至50 mg/dL， 血醋酸盐开始迅速下降。 地球表面的 血液醋酸盐浓度处于平台期表明血液醋酸盐 浓度可能与乙醇氧化的速率有关。 的 单次给药乙醇后，未处理大鼠的血液乙酸曲线具有 形状类似于身体依赖于 乙醇 乙酸盐浓度与乙醇依赖性 老鼠以前曾在人类酗酒者中发现， 饮酒模式

The blood acetate clearance curve had a biphasic character during the ethanol withdrawal period in ethanol-dependent rats. Blood acetate concentrations remained relatively stable for 15 to 20 hours, during which time blood ethanol was removed in a rectilinear fashion. Blood acetate concentrations remained on a plateau at approximately 8 to 9 mg/dL. When blood ethanol concentration decreased to approximately 80 to 50 mg/dL, blood acetate began to decrease very rapidly. The leveling off of the blood acetate concentrations at a plateau suggests that blood acetate concentrations are probably related to the rate of ethanol oxidation. The blood acetate curve of naive rats after a single dose of ethanol had a shape similar to the acetate curve in rats rendered physically dependent on ethanol. Concentrations of acetate similar to those in ethanol-dependent rats have been previously found in human alcoholics participating in a free drinking paradigm.