NEUROBIOLOGICAL CORRELATES OF ETHANOL INTOXICATION AND DEPENDENCE

儿童酒精中毒和成瘾的神经生物学相关性 研究了对乙醇产生身体依赖的大鼠， 项目 我们在这项研究中的发现包括以下几点。 “外周型”苯二氮卓类结合位点可能更相关 在神经化学后果方面， 乙醇依赖。 (With利用放射受体结合 技术，[H-3]-R 05 -4864的结合增加20-50%（“外周”结合）。 型”配体）与源自大鼠大脑皮层的脑膜结合， 小脑和海马中观察到乙醇依赖性大鼠）。 这些增加持续5至7天后退出， 乙醇 在检查的所有脑区中， “中枢型”苯二氮卓受体。 这个项目已经完成。

The neurobiological correlates of alcohol intoxication and addiction in rats rendered physically dependent upon ethanol were investigated in this project. Our findings during this study included the following. "Peripheral type" benzodiazepine binding sites were possibly more relevant than "central type" receptors in regard to the neurochemical consequences of ethanol dependency. (With utilization of the radioreceptor binding technique, 20-50% increases in the binding of [H-3]-R05-4864 (a "peripheral type" ligand) to brain membranes derived from the rat cerebral cortex, cerebellum, and hippocampus were observed in ethanol-dependent rats.) These increases persisted for 5 to 7 days following withdrawal from ethanol. In all the brain areas examined, no changes were observed in the "central type" benzodiazepine receptor. This project has been completed.