Improving the Diagnosis and Treatment of Localised Prostate Cancer

改善局限性前列腺癌的诊断和治疗

• 批准号: G1002509/1
• 负责人: Hashim Ahmed
• 金额: $ 156.31万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002509%2F1
• 关键词: Improving; Diagnosis; Treatment; Localised; Prostate

The way we diagnose prostate cancer at the moment is flawed. At present, a blood test called the prostate specific antigen, or PSA, is used to decide who gets a prostate biopsy. Prostate biopsy is painful, causes bleeding and sometimes serious infections. It often detects harmless cancers that need no treatment and misses important cancers that do. This is because prostate biopsies are random - we cannot see the cancer so needles are fired into the prostate in the hope that we will hit the cancer. Once diagnosed, the way we treat early prostate cancer can cause a lot of harm. Current treatments for early prostate cancer target the whole prostate, causing damage to surrounding structures. This can lead to urine leak, poor erections and back passage problems.The researchI will test the ability of several markers in blood and urine as well as imaging to accurately predict the presence or absence of important prostate cancer. I will also test whether treating the cancer only, in order to avoid damaging surrounding structures, is effective in cancer control and whether the harms of whole-gland treatments can be reduced.The possible benefitsReduce the number of men who undergo unnecessary prostate biopsyReduce the risk of being diagnosed with a harmless prostate cancerImprove the diagnosis of prostate cancer that is importantReduce the harms of treatment

我们目前诊断前列腺癌的方式是有缺陷的。目前，一种名为前列腺特异性抗原(PSA)的血液测试被用来决定谁接受了前列腺活检。前列腺活检很痛苦，会导致出血，有时还会引起严重感染。它经常检测到不需要治疗的无害癌症，而错过了需要治疗的重要癌症。这是因为前列腺活检是随机的--我们看不到癌症，所以针头被射入前列腺，希望我们能击中癌症。一旦确诊，我们治疗早期前列腺癌的方式可能会造成很大的伤害。目前治疗早期前列腺癌的方法是针对整个前列腺癌，对周围结构造成损害。这可能会导致尿漏、勃起不良和后排问题。这项研究将测试血液和尿液中的几种标志物以及成像的能力，以准确预测是否有重要的前列腺癌。我还将测试单独治疗癌症是否在癌症控制中有效，以避免损害周围结构，以及全腺体治疗的危害是否可以减少。可能的好处减少接受不必要的前列腺活检的男性数量降低被诊断为无害的前列腺癌的风险提高前列腺癌的诊断这一点很重要