Structural characterisation of the tetrasome and histone chaperones
Structural characterisation of the tetrasome and histone chaperones
批准号:
G1100021/1
负责人:
Tom Owen-Hughes
金额:
$56.07万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2012
资助国家:
英国
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
DNA提供了定义生命有机体的遗传信息。然而,在任何时候,只需要一定比例的基因是活跃的。调控基因何时活跃的一个重要步骤是它们的可及性。在这项提案中,我们将研究DNA包装的早期步骤。这对于了解基因在人类中是如何调控的,以及在一系列广泛的人类疾病中出了什么问题是至关重要的。
英文摘要
DNA provides the genetic information that defines living organisms. However, at any one time only a proportion of genes are required to be active. An important step in regulating when genes are active is how accessible they are. In this proposal we will investigate the early steps in the packaging of DNA. This is fundamental to understanding how genes are regulated in humans and what goes wrong in a broad range of human diseases.
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会议论文
Structure and function of chromatin remodelling ATPase's and their dysfunction in in human disease.
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批准号:MR/S021647/1
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项目类别:Research Grant
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资助金额:$157.09万
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财政年份:2019
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负责人:Tom Owen-Hughes
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依托单位:
Imaging chromatin transitions using high performance microscopy
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批准号:BB/K008676/1
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项目类别:Research Grant
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资助金额:$39.66万
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财政年份:2013
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负责人:Tom Owen-Hughes
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依托单位:
海外基金