Regulators of WIP function and podosome activity

感染后，人类的正常免疫反应始于免疫系统的监视细胞（称为树突细胞和组织巨噬细胞）捕获外来颗粒。树突状细胞随后将从其所在的组织向淋巴结迁移，在淋巴结中它们可以与淋巴细胞相互作用，并告知它们所遇到的外来颗粒的性质。淋巴细胞随后会产生针对感染因子的抗体反应。显然，如果树突状细胞或巨噬细胞不能正常迁移，则很可能出现针对感染的免疫反应故障。这项研究将调查正常骨髓细胞迁移的分子基础，并研究为什么它在人类的某些遗传异常中出错。

Following infection, the normal immune response in humans begins with the capture of foreign particles by the surveillance cells of the immune system called dendritic cells and tissue macrophages. Dendritic cells will subsequently migrate from the tissues in which they reside towards lymph nodes where they can interact with lymphocytes and inform them of the nature of the foreign particles they have encountered. Lymphocytes will then mount the antibody response to the infectious agent.Obviously, if dendritic cells or macrophages fail to migrate properly, a malfunction in the immune response to infetion is likely. The work to be carried out in this study will investigate the molecular basis of normal myeloid cell migration as well as examine why it goes wrong in some genetic abnormalities of humans.