Highly accelerated quantitative MRI of skeletal and cardiac muscle in muscular dystrophy and type 2 diabetes

肌营养不良症和 2 型糖尿病中骨骼肌和心肌的高度加速定量 MRI

• 批准号: G1100160/1
• 负责人: Kieren Hollingsworth
• 金额: $ 38.4万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100160%2F1
• 关键词: Highly; accelerated; quantitative; MRI; skeletal

Magnetic resonance imaging (MRI) has revolutionised clinical medical imaging and research by providing repeatable, non-invasive measurements of tissue structure and function. Since its invention, scanning efficiency has improved due to scientific developments in hardware and software. Even so, MRI examinations tend to concentrate on one part of the body and usually last no longer than 1 hour. This is a problem if we want to study a disease which affects more than one body part (ie muscle and heart), since the exam will take several hours. This is (1) difficult for some patients to bear (children, adults with breathing difficulties) and (2) very expensive, which means that less research can be performed.This aim of this project is to reduce the time required to get the images by a factor of three. The basic principle is familiar: in digital photography, photos are stored using compressed techniques such as JPEG which use the fact that large areas of the image are the same. This research takes this idea further. By knowing the properties of an image we want to acquire we can compress the acquisition of the data, not just the storage, so that the scan time is reduced by at least factor three . New mathematical techniques will be used to optimise the compression as much as possible to see if reductions greater than two-thirds are possible. The accelerated method will be validated for two important clinical conditions: for measuring skeletal and cardiac muscle damage in muscular dystrophy and measuring excess fat accumulation in the liver and pancreas in type 2 diabetes.There are presently no established cures for the muscular dystrophies, where healthy muscle tissue is replaced by fibrosis and fat. It affects both skeletal muscle and cardiac muscle. MRI has the ability to measure the amount of fat going into the muscles, which is useful for measuring how the disease has progressed between two points in time. Cardiac MRI is known to be the most sensitive method of detecting early damage. Now that trials of therapies are moving from animal models to the first human trials, there is an urgent need to measure the response of skeletal and cardiac muscle to determine the benefits/drawbacks of the intervention. This research develops a method of significantly speeding up the acquisition of this information, to take 40 minutes rather than 2 hours.

磁共振成像（MRI）通过提供可重复的、非侵入性的组织结构和功能测量，彻底改变了临床医学成像和研究。自其发明以来，由于硬件和软件的科学发展，扫描效率得到了提高。即便如此，核磁共振检查往往集中在身体的一个部位，通常持续不超过1小时。如果我们想研究一种影响多个身体部位（如肌肉和心脏）的疾病，这是一个问题，因为检查需要几个小时。这(1)对一些患者（有呼吸困难的儿童和成人）来说难以承受，(2)非常昂贵，这意味着可以进行的研究较少。这个项目的目的是将获得图像所需的时间减少三倍。基本原理大家都很熟悉：在数码摄影中，照片是用JPEG等压缩技术存储的，这种技术利用了图像的大部分区域是相同的这一事实。这项研究进一步证实了这一观点。通过了解我们想要获取的图像的属性，我们可以压缩数据的获取，而不仅仅是存储，这样扫描时间至少减少了三倍。新的数学技术将用于尽可能优化压缩，看看是否有可能减少超过三分之二。这种加速方法将在两种重要的临床条件下得到验证：用于测量肌肉萎缩症患者的骨骼和心肌损伤，以及用于测量2型糖尿病患者肝脏和胰腺中的多余脂肪积累。肌肉萎缩症是指健康的肌肉组织被纤维化和脂肪所取代，目前还没有确定的治疗方法。它会影响骨骼肌和心肌。核磁共振成像能够测量进入肌肉的脂肪量，这对于测量疾病在两个时间点之间的进展情况很有用。众所周知，心脏MRI是检测早期损伤最敏感的方法。现在，治疗试验正从动物模型转向首次人体试验，因此迫切需要测量骨骼肌和心肌的反应，以确定干预的利弊。这项研究开发了一种显著加快获取这些信息的方法，只需40分钟，而不是2小时。