Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
基本信息
- 批准号:10677551
- 负责人:
- 金额:$ 60.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccelerationAcuteAddressAffectAgeAtlasesBehavior TherapyBiological MarkersBody Weight decreasedBody mass indexCalibrationCartilageClinicalClinical ProtocolsCollaborationsDataData AnalysesDedicationsDegenerative polyarthritisDevelopmentDiagnosisDietDiseaseDisease ProgressionEarly DiagnosisEarly treatmentEvaluationExerciseGenderImageImpairmentIndustrializationInterventionMagnetic Resonance ImagingMapsMeasurementMeasuresMethodsModelingMorphologyMusculoskeletalPatientsPersonsPharmaceutical PreparationsPilot ProjectsPreventionPrevention strategyPrognosisProtocols documentationQuality of lifeReference ValuesRelaxationRiskScanningSiteSourceStandardizationSystemT2 weighted imagingTechniquesTechnologyTimeTravelUncertaintyVariantVendoranterior cruciate ligament rupturecancer imagingcartilage degradationclinical practiceclinical translationearly detection biomarkersheart imaginghuman subjectimaging biomarkerimaging modalityimprovedjoint functionliver imagingmulti-site trialmusculoskeletal imagingneuralneuroimagingnovelpalliationprecision medicinequantitative imagingsynergismtooltreatment effect
项目摘要
PROJECT SUMMARY/ABSTRACT
MRI relaxometry has been applied to improve early diagnosis and prognosis for a wide range of diseases.
However, one typical obstacle of integrating quantitative MRI into clinical protocols is the long acquisition time.
Furthermore, it is an essential but sometimes overlooked step to investigate quantification variability across sites
and MR systems in order to validate MR imaging biomarkers and to apply the measures in large scale multi-
vendor multi-site trials. Specifically, there is a lack of systematic evaluation of inter-vendor inter-site variability of
T1ρ imaging, even though it has been widely applied in neural-, liver-, cardiac-, oncology-, and musculoskeletal-
(MSK) imaging. Neither commercial T1ρ phantoms are available. The proposed study is addressing these
significant gaps and aims to develop and cross-validate novel fast MR T1ρ and T2 imaging methods on MR
systems from multiple vendors, followed by feasibility evaluation in patients at risk for osteoarthritis. Osteoarthritis
(OA) affects over 27 million people in the US. No disease modifying OA drugs (DMOADs) are available, despite
extensive effort. One hurdle for developing DMOADs is the lack of sensitive and reliable non-invasive biomarkers
that can detect treatment effects over a short time window. Such biomarkers would also benefit clinical practice
by identifying patients at risk for developing OA or at an early disease stage, when behavior modification
strategies are shown to be most effective in slowing down the disease progression. There is a pressing, unmet
clinical need for robust assessment of early degeneration, which is critical to support a paradigm shift of OA
management from palliation of late disease towards prevention through early diagnosis and early
treatment/interventions. Cartilage MR T1ρ and T2 measures have been shown to be promising imaging
biomarkers for early cartilage degeneration. However, many challenges remain to clinically applying these
techniques, including lack of standardized acquisition and analysis methods, long acquisition time, and
uncertainty of variations between different MR systems. In this study, we will develop novel accelerated T1ρ and
T2 imaging methods, implement these techniques on MR systems of three major vendors (Siemens, GE and
Philips), systematically evaluate inter-vendor inter-site variation of these measures using dedicated T1ρ and T2
calibration phantoms (to be developed in this study) and traveling subjects, investigate the source(s) and
magnitude of the differences, explore methods to mitigate the variability, and demonstrate the feasibility of the
newly developed acceleration techniques to quantify cartilage degeneration longitudinally in a multi-vendor
setting. Successful implementation of the proposed study will provide a full package of T1ρ and T2 imaging that
will be ready for dissemination and will help to pave the way towards large-scale multi-vendor, multi-site trials
using T1ρ and T2 imaging, facilitate clinical translation of these quantitative MR techniques, and ultimately
transform patient management of OA and other disorders using quantitative imaging biomarkers.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xiaojuan Li其他文献
Xiaojuan Li的其他文献
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{{ truncateString('Xiaojuan Li', 18)}}的其他基金
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
- 批准号:
10861563 - 财政年份:2023
- 资助金额:
$ 60.37万 - 项目类别:
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- 批准号:
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Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
在 2 型糖尿病和心力衰竭的新治疗时代优化老年人护理:通过新方法和证据三角测量加强因果推理
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$ 60.37万 - 项目类别:
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
多供应商多站点新型加速 MRI 松弛测量
- 批准号:
10396509 - 财政年份:2020
- 资助金额:
$ 60.37万 - 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
- 批准号:
10709528 - 财政年份:2020
- 资助金额:
$ 60.37万 - 项目类别:
Enhanced MR for morphological characterization of ligaments, tendons and bone
增强 MR 用于韧带、肌腱和骨骼的形态表征
- 批准号:
10246251 - 财政年份:2020
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$ 60.37万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
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$ 60.37万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
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$ 60.37万 - 项目类别:
Imaging post-traumatic osteoarthritis 10-years after ACL reconstruction: a multicenter cohort study with quantitative MRI
ACL 重建 10 年后创伤后骨关节炎的影像学:定量 MRI 的多中心队列研究
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