Developmental Clinical Studies: Does GM-CSF restore effective neutrophil function in critically ill patients?
发育临床研究:GM-CSF能否恢复危重患者有效的中性粒细胞功能?
基本信息
- 批准号:G1100233/1
- 负责人:
- 金额:$ 45.2万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2011
- 资助国家:英国
- 起止时间:2011 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Patients admitted to intensive care units (ICUs) are at very high risk of developing new infections in hospital. These hospital infections are commonly caused by bacteria that do not respond to antibiotics and are often termed ?superbugs?. Patients in ICU who develop new infections are more likely to die, or to have longer stays in ICU. Despite a variety of approaches aiming to prevent these hospital infections, they remain unacceptably common in the ICU.We have recently shown that the key blood cells (called neutrophils) mainly responsible for fighting bacteria commonly fail to work efficiently in ICU patients. This seems to contribute to the increased risk of infection. Adding a drug (GM-CSF) to such non-functioning neutrophils in the laboratory invariably improves their function. This suggests that, if high-risk patients with poorly functioning neutrophils could be identified, GM-CSF may be able to prevent infections. However GM-CSF has never been specifically targeted to ICU patients with non-functioning neutrophils before. The next crucial step in establishing whether GM-CSF may prevent infections in ICU is therefore to test whether GM-CSF improves the function of neutrophils in high-risk patients.Our aim is therefore to identify ICU patients who have poorly functioning neutrophils, using a simple laboratory test. The patients will be randomly assigned to receive either GM-CSF or a dummy drug (placebo). Neither the patient nor the doctors will be aware whether GM-CSF or placebo has been given until after the project is completed, when the research team will analyse the results. This type of study is called a randomised placebo controlled double blind trial and is widely accepted to be the best way to find out if a treatment really works or not. In this way we shall establish whether GM-CSF improves the function of neutrophils. If this ?proof of concept? study does demonstrate benefit for GM-CSF, it would rapidly pave the way for large studies establishing if GM-CSF can prevent development of infection in ICU when targeted specifically at patients whose neutrophils function poorly.
入住重症监护病房(icu)的患者在医院发生新感染的风险非常高。这些医院感染通常是由抗生素无效的细菌引起的,通常被称为“超级细菌”。在ICU中出现新感染的患者更有可能死亡,或在ICU中停留更长时间。尽管有多种方法旨在预防这些医院感染,但它们在ICU中仍然是不可接受的常见现象。我们最近的研究表明,在ICU患者中,主要负责对抗细菌的关键血细胞(称为中性粒细胞)通常不能有效地工作。这似乎增加了感染的风险。在实验室中给这些无功能的中性粒细胞添加一种药物(GM-CSF)总是能改善它们的功能。这表明,如果能够识别出功能不良的嗜中性粒细胞的高危患者,GM-CSF可能能够预防感染。然而,GM-CSF以前从未专门针对无功能中性粒细胞的ICU患者。因此,确定GM-CSF是否可以预防ICU感染的下一个关键步骤是测试GM-CSF是否可以改善高危患者中性粒细胞的功能。因此,我们的目的是使用简单的实验室测试来识别功能不良的中性粒细胞ICU患者。患者将被随机分配接受GM-CSF或空白药物(安慰剂)。在项目完成之前,患者和医生都不会知道是否服用了GM-CSF或安慰剂,届时研究小组将分析结果。这种类型的研究被称为随机安慰剂对照双盲试验,被广泛认为是发现治疗是否真正有效的最佳方法。通过这种方式,我们将确定GM-CSF是否能改善中性粒细胞的功能。如果是这样?概念证明?研究表明GM-CSF的益处,它将迅速为大规模研究铺平道路,确定GM-CSF是否可以预防ICU感染的发展,特别是针对中性粒细胞功能低下的患者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Simpson其他文献
A Contemporaneous Model of Electricity Market Interaction with Energy Stock Market Sectors
- DOI:
10.1016/j.tej.2012.07.001 - 发表时间:
2012-07-01 - 期刊:
- 影响因子:
- 作者:
John Simpson;Goknur Buyukkara;Santosh Mon Abraham - 通讯作者:
Santosh Mon Abraham
Assessment of the accuracy of truebeam intrafraction motion review (IMR) system for prostate treatment guidance
- DOI:
10.1007/s13246-019-00760-7 - 发表时间:
2019-05-13 - 期刊:
- 影响因子:2.000
- 作者:
Guneet Kaur;Joerg Lehmann;Peter Greer;John Simpson - 通讯作者:
John Simpson
BTS clinical statement on aspiration pneumonia
BTS 关于吸入性肺炎的临床声明
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:10
- 作者:
A. Simpson;Jamie L. Allen;M. Chatwin;Hannah Crawford;Jo Elverson;V. Ewan;J. Forton;R. McMullan;J. Plevris;K. Renton;H. Tedd;R. Thomas;J. Legg;John Simpson - 通讯作者:
John Simpson
The role of cytology in the diagnosis of paget’s disease of the nipple
- DOI:
10.1080/00313029600169084 - 发表时间:
1996-01-01 - 期刊:
- 影响因子:
- 作者:
Raj K. Gupta;John Simpson;Carl Dowle - 通讯作者:
Carl Dowle
Directional coronary atherectomy for angiographically unfavorable lesions
- DOI:
10.1016/0735-1097(90)91947-s - 发表时间:
1990-02-01 - 期刊:
- 影响因子:
- 作者:
Matthew Selmon;Michael Rowe;John Simpson;Gregory Robertson;James Leggett;Mary Ellen Sipperly;Tomoaki Hinohara - 通讯作者:
Tomoaki Hinohara
John Simpson的其他文献
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{{ truncateString('John Simpson', 18)}}的其他基金
MICA: Key mechanisms underlying inhaled GM-CSF's enhancement of phagocytosis and bacterial clearance by human alveolar macrophages.
MICA:吸入 GM-CSF 增强人肺泡巨噬细胞吞噬作用和细菌清除的关键机制。
- 批准号:
MR/X005046/1 - 财政年份:2023
- 资助金额:
$ 45.2万 - 项目类别:
Research Grant
MICA: Can interferon gamma prevent infection in critically ill patients at highest risk? A phase II randomised controlled trial.
MICA:γ 干扰素能否预防高风险危重患者的感染?
- 批准号:
MR/X004929/1 - 财政年份:2022
- 资助金额:
$ 45.2万 - 项目类别:
Research Grant
Newcastle Confidence in Concept 2017
纽卡斯尔对 2017 年概念的信心
- 批准号:
MC_PC_17168 - 财政年份:2018
- 资助金额:
$ 45.2万 - 项目类别:
Intramural
Stratified interventions in ARDS (EMINENT)
ARDS 的分层干预措施 (EMINENT)
- 批准号:
MR/P502066/1 - 财政年份:2017
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$ 45.2万 - 项目类别:
Research Grant
Newcastle Confidence in Concept 2016
纽卡斯尔对 2016 年概念的信心
- 批准号:
MC_PC_16054 - 财政年份:2017
- 资助金额:
$ 45.2万 - 项目类别:
Intramural
Newcastle Confidence in Concept 2015
纽卡斯尔对 2015 年概念的信心
- 批准号:
MC_PC_15030 - 财政年份:2016
- 资助金额:
$ 45.2万 - 项目类别:
Intramural
Strengthening Aquatice Science Programs in Secondary and Postsecondary Schools Using Distance Education Technologies
利用远程教育技术加强中学和专上学校的水生科学项目
- 批准号:
0053308 - 财政年份:2000
- 资助金额:
$ 45.2万 - 项目类别:
Standard Grant
Gadsden State Community College: A Regional Center for Integrating Aquaculture Technologies in Secondary and Two-year Schools
加兹登州立社区学院:在中学和两年制学校中整合水产养殖技术的区域中心
- 批准号:
9950063 - 财政年份:1999
- 资助金额:
$ 45.2万 - 项目类别:
Standard Grant
Solar Flare and Solar Interplanetary Phenomena Investigated with High Energy Charged Particles
用高能带电粒子研究太阳耀斑和太阳行星际现象
- 批准号:
9613963 - 财政年份:1997
- 资助金额:
$ 45.2万 - 项目类别:
Continuing Grant
Solar Flare and Solar Interplanetary Phenomena Investigated with High Energy Charged Particles
用高能带电粒子研究太阳耀斑和太阳行星际现象
- 批准号:
9420790 - 财政年份:1995
- 资助金额:
$ 45.2万 - 项目类别:
Continuing Grant
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