Intermittent screening and treatment or intermittent preventive therapy for control of malaria in pregnancy in Indonesia

印度尼西亚妊娠期疟疾的间歇性筛查和治疗或间歇性预防性治疗

• 批准号: G1100654/1
• 负责人: Feiko Ter Kuile
• 金额: $ 309.12万
• 依托单位: Liverpool School of Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100654%2F1
• 关键词: Intermittent; screening; treatment; intermittent; preventive

FIGHTING MALARIA IN PREGNANCY IN INDONESIAThe control of malaria in pregnancy in Indonesia, where approximately 10% of pregnant women get infected with malaria, could receive a potential boost through a new study conducted by the Eijkman Institute for Molecular Biology and the Timika Research Facility in Indonesia. Together with experts from the Liverpool School of Tropical Medicine in the UK, they are going to test two new methods of preventing malaria and the harmful effects in pregnancy. When pregnant women contract malaria this can have devastating consequences for pregnancy, resulting in fever which may trigger preterm onset of labour or even pregnancy loss. It is also possible for women to be infected without showing any outward signs or symptoms, yet if these infections are undetected and left untreated, they can cause anaemia in the mother and can interfere with the growth of the fetus leading to low birth weight, which increases the risk of babies dying during infancy.The new project will provide malaria testing to women with or without the symptoms of malaria on every scheduled antenatal visit using a rapid diagnostic test (RDT). The RDT is simple to perform, uses a single drop of blood and gives results within 15 minutes. Those women testing positive will be treated with an artemisinin combination drug called dihydroartemisinin-piperaquine (DHP), which is the treatment of choice in the 2nd and 3rd trimester of pregnancy in Indonesia. A second method called intermittent preventive treatment, which is used in most countries in Africa but not yet in Asia, will also be tested. With this method women without symptoms of malaria will be selected to receive the same drug but without prior blood testing. Both methods will be compared with the existing policy in Indonesia, where all pregnant women are tested for malaria on the first antenatal visit only, and those with a positive result are treated with DHP. During subsequent antenatal visits, women are only tested if they have symptoms of malaria such as fever. This means that some infections will go undetected. It is anticipated that the two new methods will either detect infections much earlier than the current approach, or prevent them altogether.The findings of this study, together with an assessment of feasibility and cost effectiveness of each method, will be used to inform malaria prevention policy for pregnant women in Indonesia and other parts of South East Asia.

在印度尼西亚，大约10%的孕妇感染疟疾，通过艾伊克曼分子生物学研究所和印度尼西亚蒂米卡研究机构进行的一项新研究，印度尼西亚控制怀孕期间疟疾可能会得到潜在的促进。他们将与英国利物浦热带医学院的专家一起测试两种预防疟疾的新方法及其对怀孕的有害影响。当孕妇感染疟疾时，这可能会对怀孕造成毁灭性的后果，导致发烧，从而可能引发早产甚至流产。妇女也有可能在没有任何外在迹象或症状的情况下被感染，但如果这些感染没有被发现和治疗，它们可能会导致母亲贫血，并可能干扰胎儿的生长，导致低出生体重，从而增加婴儿在婴儿期死亡的风险。新项目将使用快速诊断测试(RDT)在每次预定的产前检查中为有或没有疟疾症状的妇女提供疟疾检测。RDT操作简单，只需一滴血，15分钟内就能得出结果。那些检测呈阳性的妇女将接受名为双氢青蒿素-哌喹(DHP)的青蒿素联合药物治疗，这是印度尼西亚怀孕第二和第三个月的首选治疗方法。另一种名为间歇预防性治疗的方法也将接受测试，这种方法在非洲大多数国家都在使用，但在亚洲还没有。通过这种方法，没有疟疾症状的妇女将被选中接受相同的药物治疗，但不需要事先进行血液测试。这两种方法都将与印度尼西亚的现行政策进行比较，在印度尼西亚，所有孕妇只在第一次产前检查时接受疟疾检测，结果呈阳性的孕妇将接受DHP治疗。在随后的产前检查中，只有在妇女出现疟疾症状(如发烧)时才对她们进行检测。这意味着一些感染将不会被发现。预计这两种新方法要么比目前的方法更早发现感染，要么共同预防感染。这项研究的结果，以及对每种方法的可行性和成本效益的评估，将被用于为印度尼西亚和东南亚其他地区的孕妇制定预防疟疾的政策。