E Ochodo, Stellenbosch University, Evidence synthesis for building a translation pipeline to eliminate infectious diseases

艾滋病毒、结核病和疟疾等传染病仍然在非洲造成大量疾病和死亡。尽管疟疾和结核病是可治疗的，有检测这些疾病的检测方法，也有使艾滋病毒感染者健康正常化的治疗方法，但这种情况仍然存在。对此的一个可能解释是，用于实施或转化研究结果以告知政策的方法无效。研究性翻译包括将正确的信息以正确的格式传递给正确的人，使他们易于理解，从而为决策提供信息。一项政策实施得太快或太慢都会使疾病的有效控制最小化。做到这一点很重要，需要严格的方法和科学来帮助确保这一点。总结现有的研究成果并以易于解释和理解的方式呈现（也称为证据综合）有助于决策。干预措施的使用决策与实际使用之间存在多种影响因素。需要综合不同领域的研究成果，包括技术方面、成本、可接受性和实用性，但综合方法尚不清楚。我们的愿景是通过总结不同领域的研究成果，为政策、政策的实施和政策的修订提供信息，从而建立更广泛的研究成果基础，以供实施。在非洲，关于改进如何总结研究成果以及如何改进将研究成果转化为政策的方法的研究和发展有限。需要有适合非洲情况的研究方法，以促进该区域更好地吸收和可持续性。本项目旨在通过总结和整合不同领域的研究成果，正式开发一种将研究成果转化为政策的方法。我们还旨在推荐改进将证据转化为政策的方法。最终，通过这个项目，我们的目标是在肯尼亚建立一个研究小组，并在未来建立一个证据综合和研究转化科学的次区域中心。据我们所知，肯尼亚还不存在这样一个指导或协调中心。这个项目的目标是：1。根据肯尼亚的国家优先事项，总结新的和现有的艾滋病毒、结核病和疟疾干预措施的效果和交付情况。制定和实施总结和整合不同领域的研究成果和知识的方法。通过总结和整合研究和知识，对所产生的评论进行总结。向决策者传播和传播这种综合方法的专门知识和产品。在实现这一目标的过程中，我们将在肯尼亚建立一个研究小组，负责艾滋病毒、结核病和疟疾的证据合成和研究转化。这个项目很及时，有很大的影响潜力。在新的领导下，世界卫生组织（世卫组织）明确转向将决策权力下放到区域一级。未来需要在非洲的研究基础设施中牢牢地植入证据综合控制的地位。这个项目的研究结果将对肯尼亚的决策者有用，他们需要在决策时整合来自不同领域的研究成果的能力。

Infectious diseases such as HIV, tuberculosis (TB) and malaria still cause considerable illness and death in Africa. This is despite malaria and TB being treatable, the availability of tests to detect these diseases and the presence of treatment to normalize the health of people living with HIV. One possible explanation for this could be the ineffective ways used to implement or translate findings of research to inform policy. Research translation involves getting the right information to the right people at the right format they can easily understand to inform decision-making. A policy that is implemented too rapidly or too slowly can minimize effective control of disease. Getting this right is important and needs rigorous methods and science to help assure this.Summarizing available research findings and presenting it in a way that can be easily interpreted and understood (otherwise known as evidence synthesis) can help in decision making. Multiple influencing factors exist between the decision to use an intervention and its use in practice. A portfolio of integrated research findings from different fields including technical aspects, costs, acceptability and practicality is needed but methods of integration are still unclear. Our vision is a broader base of research findings for implementation being supported by summarising research findings from different fields to inform policy, implementation and revisions of policies.In Africa, there has been limited research and development on methods to improve how research findings are summarised and how to improve translation of research findings to policy. Research methods tailored to the African context are needed to facilitate better uptake and sustainability in the region. This project aims to formally develop an approach to translating research findings into policy through summarizing and integrating research findings from different fields. We also aim to recommend methods of improving translation of evidence into policy. Ultimately, through this, we aim to establish a research group and in future a sub-regional centre for the science of evidence synthesis and research translation in Kenya. To our knowledge such a directive or coordinating centre does not yet exist in Kenya. The objectives of this project are:1. To summarize the effect and delivery of new and existing interventions on HIV, TB and malaria per national priorities of Kenya.2. To develop and implement methods of summarizing and integrating research findings and knowledge from different fields.3. To develop summaries of reviews generated by summarizing and integrating research and knowledge.4. To communicate and circulate know-how and products of this integrative approach to policy makers.In the process of achieving this, we will establish a research group in evidence synthesis and research translation in HIV, TB and malaria in Kenya.This project is timely and has potential for great impact. Under new leadership, there is an explicit shift in the World Health Organization (WHO) to devolve policy making to regional level. The future requires the position of control for evidence synthesis to be firmly implanted in the research infrastructure in Africa. The findings of this project will be useful to policy makers in Kenya who require capacity to integrate research findings from different areas when making decisions.