课题基金 / 基金详情

POST-TRANSFUSION HEPATITIS (PTH) IN OPEN HEART SURGERY PATIENTS

POST-TRANSFUSION HEPATITIS (PTH) IN OPEN HEART SURGERY PATIENTS
心脏直视手术患者的输血后肝炎 (PTH)
批准号：
4691943
负责人：
H J ALTER
金额：
$0.0万
依托单位：
CLINICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4691943
关键词：
Betaherpesvirinae DNA directed DNA polymerase Epstein Barr virus alanine transaminase blood donor blood transfusion chronic disease /disorder communicable disease control epidemiology heart surgery hepatitis B antigens hepatitis C virus human subject longitudinal human study microorganism immunology nosocomial infection control postoperative complications radioimmunoassay serology /serodiagnosis virus classification

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中文摘要
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英文摘要
To determine the incidence of hepatitis in prospectively followed open heart surgery patients receiving blood which has been pre-screened for donor transaminase (ALT) level. Blood units with elevated ALT will be discarded. Hepatitis incidence will be compared with that of identically followed patients in a recently completed study in which no attempt was made to exclude blood with elevated ALT. In that study blood units with elevated ALT were more frequently associated with recipient hepatitis than units with normal ALT. Cases of hepatitis will be serologically assessed for virus etiology and patients will be carefully followed for the development of chronic hapatitis.
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