NEW APPROACHES TO TREATMENT OF GASTROINTESTINAL CANCER

该项目的目的是将下列人员聚集在一个协调的单位中： 马约诊所的临床研究学科和相关实验室 为了改善姑息和治愈治疗的目的， 人胃肠癌。 以下具体领域将 治疗方法：1）治疗大肠癌。 2)治疗胃和 胰腺癌 3)治疗不常见的胃肠道疾病 癌和4）胃肠癌药理学。 特别强调 将致力于开发和测试创新方法， 局部疾病和以治愈为特定目的的外科辅助治疗 点 最重要的是直接融入 癌症复杂实验室的临床研究项目 药理学 该计划的特别优势包括一个无与伦比的 在胃肠道临床癌症研究方面有着丰富的经验; 临床研究团队，包括所有相关学科; 马约诊所的癌症患者人数异常庞大 允许及时进行有意义的研究; 新诊断的胃肠道疾病患者的独特人群 癌症允许进行早期疾病研究;一个非常 胃肠道癌症患者人数众多，发病率较低; 与我们地区的社区诊所建立了牢固的关系， 管理的连续性和相同数据的扩展III期试验 基地;和发达的马约癌症中心统计单位， 参与我们研究的所有阶段，以确保合理的方案设计， 一致的数据质量以及知情和客观的数据分析。 我们 我相信这些因素与我们现有的生产力相结合 提供最大的信心，建议的工作将满足最高 科学的标准，并将以无与伦比的成本进行 有效性

This project is designed to bring together in a coordinated unit the clinical research disciplines and related laboratories of the Mayo Clinic for the purpose of improving both palliative and curative treatment of human gastrointestinal cancer. The following specific areas will be addressed: 1) Treatment of colorectal cancer. 2) Treatment of gastric and pancreatic cancer. 3) Treatment of the less common gastrointestinal carcinomas and 4) Gastrointestinal cancer pharmacology. Special emphasis will be placed on the development and testing of innovative approaches to regional disease and surgical adjuvant therapy with cure as a specific end point. Of primary importance will be the integration directly into clinical research programs of sophisticated laboratory endeavors in cancer pharmacology. Particular strengths of this program include an unexcelled depth of experience in gastrointestinal clinical cancer research; a devoted clinical research team including all concerned disciplines; the exceptionally large cancer patient population available at the Mayo Clinic permitting meaningful studies to be performed in a timely fashion; the uniquely large population of patients with newly diagnosed gastrointestinal cancer permitting conduct of early disease studies; an extraordinarily large population of patients with the less common gastrointestinal cancers; strong relationships with community clinics in our region permitting a continuum of management and expanded Phase III trials in the same data base; and the well developed Mayo Cancer Center Statistical Unit which is involved in all phases of our studies to insure sound protocol design, consistent data quality, and informed and objective data analysis. We believe these ingredients combined with our established productivity provide maximum confidence that the work proposed will meet highest scientific standards and will be conducted with unexcelled cost effectiveness.