NEW APPROACHES TO TREATMENT OF GASTROINTESTINAL CANCER

这个项目的设计目的是将 梅奥诊所的临床研究学科和相关实验室 为了改善姑息性和根治性治疗 人类胃肠道癌症。以下是具体的领域 地址：1)结直肠癌的治疗。2)治疗胃病和胃炎 胰腺癌。3)较少见的胃肠道疾病的治疗 癌症和4)胃肠癌药理学。特别强调 将致力于创新方法的开发和测试，以 以治愈为特定目的的局部疾病和手术辅助治疗 指向。最重要的是直接整合到 癌症尖端实验室的临床研究计划 药理学。这一计划的独特优势包括 在胃肠道癌症临床研究方面有深入的经验；致力于 包括所有相关学科的临床研究团队； 梅奥诊所提供超大数量的癌症患者 允许及时进行有意义的研究； 独特的大量新诊断的胃肠道疾病患者 癌症允许进行早期疾病研究；一种非同寻常的 较少见的胃肠道肿瘤患者人数较多； 与本地区社区诊所建立了牢固的关系，使 同一数据中的连续管理和扩展的第三阶段试验 基地；以及发展良好的梅奥癌症中心统计单位， 参与我们研究的所有阶段，以确保合理的协议设计， 始终如一的数据质量，知情和客观的数据分析。我们 相信这些要素与我们既定的生产力相结合 最大限度地相信所提议的工作将达到最高标准 科学标准，并将以无与伦比的成本进行 有效性。

This project is designed to bring together in a coordinated unit the clinical research disciplines and related laboratories of the Mayo Clinic for the purpose of improving both palliative and curative treatment of human gastrointestinal cancer. The following specific areas will be addressed: 1) Treatment of colorectal cancer. 2) Treatment of gastric and pancreatic cancer. 3) Treatment of the less common gastrointestinal carcinomas and 4) Gastrointestinal cancer pharmacology. Special emphasis will be placed on the development and testing of innovative approaches to regional disease and surgical adjuvant therapy with cure as a specific end point. Of primary importance will be the integration directly into clinical research programs of sophisticated laboratory endeavors in cancer pharmacology. Particular strengths of this program include an unexcelled depth of experience in gastrointestinal clinical cancer research; a devoted clinical research team including all concerned disciplines; the exceptionally large cancer patient population available at the Mayo Clinic permitting meaningful studies to be performed in a timely fashion; the uniquely large population of patients with newly diagnosed gastrointestinal cancer permitting conduct of early disease studies; an extraordinarily large population of patients with the less common gastrointestinal cancers; strong relationships with community clinics in our region permitting a continuum of management and expanded Phase III trials in the same data base; and the well developed Mayo Cancer Center Statistical Unit which is involved in all phases of our studies to insure sound protocol design, consistent data quality, and informed and objective data analysis. We believe these ingredients combined with our established productivity provide maximum confidence that the work proposed will meet highest scientific standards and will be conducted with unexcelled cost effectiveness.