London Neurodegenerative Diseases Brain Bank; a national resource for neuroscience research

伦敦神经退行性疾病脑库；

• 批准号: G1100695/1
• 负责人: Safa Al Saraj
• 金额: $ 63.18万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100695%2F1
• 关键词: London; Neurodegenerative; Diseases; Brain; Bank

The Brain Bank collects post-mortem brain tissue from persons with neurodegenerative diseases, such as dementia and motor neuron disease. Wherever possible data from previous clinical examinations, neuropsychological tests and neuroimaging are also collected. The brain tissue is examined by neuropathologists and disease is diagnosed according to internationally agreed criteria. Samples of brain and spinal cord tissue in various fixation states, such as frozen and formalin-fixed, are then made available to Neuroscience researchers. The purpose of the project is to provide clinically studied and pathologically verified brain tissue to facilitate and promote internationally competitive research into Neurodegenerative disease. The Brain Bank aims are to fulfill international recommendations and guidelines with regard to brain tissue banking. As such, this involves the systematic and focused collection of well-characterised post-mortem material and its subsequent distribution to research groups both regionally and nationally. This will necessarily underpin high quality and peer-reviewed research. The following is a summary of the key functions of the Brain Bank: 1. To advance the understanding of, and facilitate research into the underlying causes of neurodegenerative and neurological diseases through the provision of clinically and neuropathologically well-characterised brain tissue to the research community. 2. To facilitate brain donation through an ethically approved programme of informed consent for donation. 3. To provide pathological diagnosis to the relatives of brain donors according to best national and international protocols. 4. To coordinate the processing and dissemination of well-preserved brain tissue and maintain an open door policy of responding to requesters without prejudice. 5. To ensure donor care and keep contact with brain donor families, informing them about diagnosis and progress in research. 6. To disseminate and promote knowledge of brain banking through scientific meetings, public open days, collaboration with charities and MRC newsletters. 7. To provide professional teaching, training, information and educational resources for neuroscientists and medical trainees. 8. To facilitate collaboration between basic research scientists, pathologists and clinicians to promote transitional research to help develop new diagnostic and therapeutic strategies for brain diseases. 9. To maintain gold standards of excellence in Brain Banking for storage of frozen and formalin-fixed brain tissue. 10. To follow most recent ethical principles for best practice in Brain Banking, from consenting donors to tissue requests and strictly follow the guidelines of the Human Tissue Act.

脑库收集患有神经退行性疾病的人的死后脑组织，如痴呆症和运动神经元病。只要有可能，以前的临床检查、神经心理测试和神经成像的数据也被收集起来。脑组织由神经病理学家检查，并根据国际公认的标准诊断疾病。然后，神经科学研究人员可以获得各种固定状态下的大脑和脊髓组织样本，如冰冻和福尔马林固定。该项目的目的是提供经过临床研究和病理验证的脑组织，以促进和促进神经退行性疾病的国际竞争研究。脑库的目标是履行有关脑组织银行的国际建议和指南。因此，这涉及有系统和有重点地收集具有良好特点的尸检材料，并随后将其分发给区域和国家的研究小组。这必然会支撑高质量和同行评议的研究。以下是脑库的主要职能摘要：1.通过向研究界提供临床和神经病理特征良好的脑组织，促进对神经退行性疾病和神经疾病的根本原因的了解和促进研究。2.通过道德上认可的捐赠知情同意计划，促进脑部捐赠。3.根据最好的国家和国际协议为脑捐赠者的亲属提供病理诊断。4.协调保存完好的脑组织的处理和分发，并保持开放的政策，不带偏见地回应请求者。5.确保捐赠者的关怀，并与脑捐赠者家庭保持联系，告知他们诊断和研究进展。6.通过科学会议、公众开放日、与慈善机构合作和MRC时事通讯，传播和推广有关脑库的知识。7.为神经科学家和医学实习生提供专业的教学、培训、信息和教育资源。8.促进基础研究科学家、病理学家和临床医生之间的合作，促进过渡性研究，以帮助开发新的脑部疾病诊断和治疗策略。9.在储存冰冻和福尔马林固定的脑组织方面，维持脑库的黄金标准。10.遵循脑库最佳做法的最新伦理原则，从同意捐赠者到组织请求，并严格遵守《人类组织法》的指导方针。