London Neurodegenerative Diseases Brain Bank (LNDBB) : a national resource for the neuroscience research community

伦敦神经退行性疾病脑库 (LNDBB)：神经科学研究界的国家资源

• 批准号: G0900635/1
• 负责人: Safa Al Saraj
• 金额: $ 54.42万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900635%2F1
• 关键词: London; Neurodegenerative; Diseases; Brain; Bank

The Brain Bank collects post-mortem brain tissue from persons with neurodegenerative diseases, such as dementia and motor neuron disease. Wherever possible data from previous clinical presentations, neuropsychological tests and neuroimaging are also collected. The brain tissue is examined by neuropathologists and illness is diagnosed according to internationally agreed criteria. Samples of brain tissue in various fixation states, such as frozen and formalin-fixed, are then made available to Neuroscience research centers along with, where available, spinal cord tissue and cerebrospinal fluid. The purpose of the project is to provide clinically studied and pathologically verified brain tissue to facilitate and promote internationally competitive research into Neurodegenerative disease.The Brain Bank aims are to fulfill international recommendations and guidelines with regard to brain tissue banking. As such, this involves the systematic and focused collection of well-characterised post-mortem material and its subsequent distribution to research groups both regionally and nationally. This will necessarily underpin high quality and peer-reviewed research. The following is a summary of the key functions of the Brain Bank: 1. To advance the understanding of, and facilitate research into the underlying causes of neurodegenerative and neurological diseases through the provision of clinically and neuropathologically well-characterised brain tissue to the research community. 2. To facilitate brain donation through an ethically approved programme of informed consent for cohort studies and ad-hoc donation.3. To provide pathological diagnosis to the relatives of brain donors according to best national and international protocols.4. To coordinate the processing and dissemination of well-preserved brain tissue for clinical, biochemical, molecular pathology, genetic and transcriptional research projects, and maintain an open door policy of responding to requesters without prejudice.5. To ensure ?donor care? and keep contact with ?brain donor? families, informing them about diagnosis and progress in research.6. To disseminate and promote knowledge of brain banking through scientific meetings, public open days, collaboration with charities and MRC newsletters.7. To provide professional teaching, training, information and educational resources for neuroscientists.8. To facilitate collaboration between basic research scientists, pathologists and clinicians to promote transitional research to help develop new diagnostic and therapeutic strategies for brain diseases.9. To maintain gold standards of excellence in Brain Banking for storage of frozen and formalin-fixed brains.10. To follow most recent ethical principles for best practice in Brain Banking, from recruiting donors and consent for postmortem to tissue requests and follow strictly the guidelines of the Human Tissue Act.

脑库收集患有神经退行性疾病（如痴呆症和运动神经元疾病）的人的死后脑组织。尽可能收集以前临床表现、神经心理学测试和神经影像学的数据。脑组织由神经病理学家检查，疾病根据国际公认的标准进行诊断。然后，将处于各种固定状态（如冷冻和福尔马林固定）的脑组织样本沿着脊髓组织和脑脊液（如果可用）提供给神经科学研究中心。该项目的目的是提供临床研究和病理证实的脑组织，以促进和促进神经退行性疾病的国际竞争性研究。脑银行的目标是履行关于脑组织银行的国际建议和指南。因此，这涉及到系统和有重点地收集具有良好特征的死后材料，并随后将其分发给区域和国家的研究小组。这必然会支持高质量和同行评审的研究。以下是脑库的主要功能概述：1。通过向研究界提供临床和神经病理学特征良好的脑组织，促进对神经退行性疾病和神经系统疾病根本原因的理解和研究。2.通过伦理上批准的队列研究知情同意方案和特别捐赠来促进大脑捐赠。根据国内和国际最好的方案，为脑供体亲属提供病理诊断.协调保存完好的脑组织的处理和传播，用于临床，生物化学，分子病理学，遗传和转录研究项目，并保持不带偏见地回应请求的开放政策。为了确保？捐献者护理并保持联系大脑捐赠者家庭，告知他们诊断和研究进展。通过科学会议、公众开放日、与慈善机构的合作以及医学研究理事会的新闻通讯，传播和促进脑库知识。为神经科学家提供专业的教学、培训、信息和教育资源。促进基础研究科学家、病理学家和临床医生之间的合作，促进过渡性研究，以帮助开发新的脑部疾病诊断和治疗策略。保持大脑银行的黄金标准，以储存冷冻和福尔马林固定的大脑。遵循最新的脑库最佳实践伦理原则，从招募捐赠者和同意死后组织请求，并严格遵循《人体组织法》的指导方针。