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THE ROLE OF MOUSE CYTOCHROME P1-450 AND P3-450 IN CARCINOGENESIS

THE ROLE OF MOUSE CYTOCHROME P1-450 AND P3-450 IN CARCINOGENESIS
小鼠细胞色素 P1-450 和 P3-450 在致癌作用中的作用
批准号:
4692456
负责人:
N BATTULA
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
翻译
多环芳烃诱导氧化酶和结合酶
英文摘要
Polycyclic aromatic hydrocarbons induce oxidative and conjugative enzymes in responsive animals and in human cells. The oxidative enzymes, i.e., cytochrome P-450s, generate active intermediates from procarcinogens and thus initiate chemical carcinogenesis. We propose to investigate this hypothesis by directly introducing molecularly cloned full length P-450 cDNAs into different cells and analyzing the extent of binding of the carcinogen to the cellular macromolecules, and the incidence of tumors by challenging with appropriate carcinogens. For this purpose, we plan to use the infectious eukaryotic expression vector, vaccinia virus, which was previously shown to express enzymatically active foreign proteins that are transported to the appropriate subcellular site of residence. We have introduced the mouse P1-450 and P3-450 into the recomination vector and are in the process of transferring these into the vaccinia virus to generate the infectious recombinant vaccinia virus.
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会议论文
STRUCTURE AND EXPRESSION OF HUMAN ACTIN GENES
ROLE OF CYTOCHROMES P-450 GENES IN MUTAGENESIS AND CARCINOGENESIS
THE ROLE OF CYTOCHROME P-450 ENZYMES IN CARCINOGENESIS
EXPRESSION OF CYTOCHROME P-450S AND THEIR ROLE IN MUTAGENESIS & CARCINOGENESIS
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