ASBESTOS CARCINOGENESIS/CHROMOSOMAL CHANGES IN HUMAN CELLS

石棉致癌/人体细胞染色体变化

• 批准号: 4692445
• 负责人: K LINNAINMAA
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4692445
• 关键词: aneuploidy; asbestos; bronchus; chemical carcinogen; chemical carcinogenesis; chemical related neoplasm /cancer; chromosome aberrations; dosage; environment related neoplasm /cancer; fibroblasts; human tissue; neoplasm /cancer genetics; occupational hazard; pleural cavity; tissue /cell culture

Asbestos-induced chromosomal abnormalities have been studied in human pleural mesothelial cells and in bronchial fibroblast cultures in vitro. After one exposure to amosite, a significant increase in chromosomal aberrations was found in mesothelial cells, as compared to unexposed controls. The number of aberrant cells was further increased in cultures treated twice wth asbestos, the major aberration type being dicentric chromosomes and acentric fragments (minute chromosomes). The number of aneuploid cells was observed to increase in all the mesothelial cell cultures with the passage number of the culture. However, no significant differences were found between the asbestos-exposed and control mesothelial cells. In asbestos-exposed fibroblasts, on the other hand, the number of aneuploid cells was significantly elevated, as compared to unexposed controls.

石棉诱发的人类染色体异常已被研究过