EFFECTS OF NOISE AND DRUGS ON WATER CONTROL OF THE COCHLEAR FLUIDS

噪音和药物对耳蜗液水分控制的影响

• 批准号: 4693234
• 负责人: T KONISHI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693234
• 关键词: auditory stimulus; auditory threshold shift; biological fluid transport; body water; cochlea; cochlear microphonic potentials; drug adverse effect; electrical potential; endolymph; glycerol; membrane permeability; perilymph

The purpose of this study is to elucidate the mechanisms of water movement across the cochlear partition. Systemic injection of glycerin or deionized water was used to induce alterations in the osmolarity of the blood serum in guinea pigs. The cochlear potential including the endocochlear potential did not show marked suppression when the osmolarity of the cochlear fluids was elevated or lowered. Under normal conditions the osmolarity is significantly higher in the endolymph then perilymph. When the blood osmolarity was altered, the osmotic gradient across the cochlear partition decreased. These studies are used as base line data to which water control in the cochlear fluids under pathologic conditions can be compared.

本研究的目的是阐明水分运动的机制 穿过耳蜗分区。 全身注射甘油或去离子 用水诱导血清渗透压的改变 在豚鼠身上。 耳蜗电位包括耳蜗内电位 电位没有显示出显着的抑制时，渗透压的 耳蜗液升高或降低。 在正常情况下， 内淋巴中的渗透压显著高于外淋巴。 当 血液渗透压改变，耳蜗的渗透压梯度 分区下降。 这些研究被用作基线数据， 可以比较病理条件下的耳蜗液。