EFFECTS OF NOISE AND OTOTOXIC AGENTS ON ENERGY BALANCE AND METABOLISM IN COCHLEA

噪声和耳毒性物质对耳蜗能量平衡和代谢的影响

• 批准号: 4693230
• 负责人: T KONISHI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4693230
• 关键词: action potentials; active transport; biophysics; bromine; chlorine; cochlear lesion; cochlear microphonic potentials; drug interactions; ear hair cell; ear pharmacology; electrolytes; electrophysiology; endolymph; evoked potentials; ion transport; membrane permeability; noise biological effect; noise induced deafness; ototoxin; perilymph; potassium; sodium

The perilymphatic perfusion with artificial perilymph containing sodium bromate (1mM) was employed in guinea pigs to study the ototoxity of bromate. Changes in the cochlear potentials and electrolyte concentrations in the endolymph were measured in both control and experimental perfusions. The perilymphatic application of bromate resulted in a gradual suppression of the endocochlear potential and sound evoked responses. The recovery of the cochlear potentials was not observed. A substantial decrease in potassium and chloride concentrations and increase in sodium concentration were observed in the endolymph. Our results indicated that the primary site of action of bromate was on the stria vascularis and in advanced stage of intoxication bromate might affect the hair cells, causing a further suppression of the hair cell responses.

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