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Wellcome Trust MRC Cambridge Stem Cell Institute

Wellcome Trust MRC Cambridge Stem Cell Institute
威康信托 MRC 剑桥干细胞研究所
批准号:
MC_PC_12009
负责人:
金额:
$391.7万
依托单位:
依托单位国家:
英国
项目类别:
Intramural
财政年份:
2012
资助国家:
英国
项目状态:
已结题
起止时间:
2012 至 --

项目摘要

项目成果

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中文摘要
翻译
Wellcome Trust MRC剑桥干细胞研究所所长:剑桥大学干细胞科学教授奥斯汀·史密斯正在提供一系列关于我们身体是如何制造和维护的新知识。这项研究带来了希望,对干细胞的更好理解将导致未来的医学应用。治疗可以通过几种途径进行。首先,在实验室培养的人类干细胞可以用来制作疾病组织的实验模型,并测试治疗药物。其次,包括癌症在内的一些疾病与干细胞的异常行为有关。随着我们学习如何控制干细胞,纠正这些缺陷可能成为可能。第三,发现如何防止干细胞数量和活性下降,可能有助于在衰老过程中保持健康。最后,干细胞可以用来更新受损的组织,并在某些疾病中取代缺失的细胞。剑桥干细胞研究所正在成立,以探索和定义干细胞的特性,并建立其真正的医学潜力。领先的研究科学家、技术专家和医生将并肩工作,创建一个世界领先的干细胞生物学和医学卓越中心。该研究所还将与生物产业合作,为来自世界各地的年轻研究人员提供高水平的培训。
英文摘要
Wellcome Trust MRC Cambridge Stem Cell InstituteDirector: Professor Austin Smith, University of CambridgeStem cell science is providing a stream of new knowledge about how our bodies are made and maintained. This research brings the promise that better understanding of stem cells will lead to future medical applications. Treatments may come through several routes. First, human stem cells grown in the laboratory can be used to produce experimental models of diseased tissues and to test therapeutic drugs. Second, some disorders, including forms of cancer, involve abnormal behaviour of stem cells. As we learn how to control stem cells it may become possible to correct these faults. Third, finding how to prevent a decline in numbers and activity of stem cells may help to maintain health during ageing. Finally, stem cells could be used to renew damaged tissues and replace missing cells in certain disorders.The Cambridge Stem Cell Institute is being formed to explore and define the properties of stem cells and establish their true medical potential. Leading research scientists, technology specialists and doctors will work side by side to create a world-leading centre of excellence in stem cell biology and medicine. The Institute will also collaborate with bioindustry and will provide high level training for young researchers from around the world.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
Prediction of acute myeloid leukaemia risk in healthy individuals.
在健康个体中预测急性髓样白血病的风险。
DOI: 10.1038/s41586-018-0317-6
发表时间: 2018-07
期刊: Nature
影响因子: 64.8
作者: [Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI]
通讯作者: Shlush LI
Oesophageal Stem Cells and Cancer.
食管干细胞和癌症。
DOI: 10.1007/978-3-319-69194-7_10
发表时间: 2017
期刊: Advances in experimental medicine and biology
影响因子: --
作者: [Alcolea MP]
通讯作者: Alcolea MP
DOI: 10.1038/s41598-020-73802-w
发表时间: 2020-10-07
期刊: Scientific reports
影响因子: 4.6
作者: [Aalders J, Léger L, Van der Meeren L, Van den Vreken N, Skirtach AG, Sinha S, De Backer J, van Hengel J]
通讯作者: van Hengel J
DOI: 10.1158/1541-7786.mcr-20-0693
发表时间: 2020-12
期刊: Molecular cancer research : MCR
影响因子: --
作者: [Ali FR, Marcos D, Chernukhin I, Woods LM, Parkinson LM, Wylie LA, Papkovskaia TD, Davies JD, Carroll JS, Philpott A]
通讯作者: Philpott A
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