Wellcome Trust MRC Cambridge Stem Cell Institute

威康信托 MRC 剑桥干细胞研究所

• 批准号: MC_PC_12009
• 金额: $ 391.7万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12009
• 关键词: Wellcome; Trust; MRC; Cambridge; Stem

Wellcome Trust MRC Cambridge Stem Cell InstituteDirector: Professor Austin Smith, University of CambridgeStem cell science is providing a stream of new knowledge about how our bodies are made and maintained. This research brings the promise that better understanding of stem cells will lead to future medical applications. Treatments may come through several routes. First, human stem cells grown in the laboratory can be used to produce experimental models of diseased tissues and to test therapeutic drugs. Second, some disorders, including forms of cancer, involve abnormal behaviour of stem cells. As we learn how to control stem cells it may become possible to correct these faults. Third, finding how to prevent a decline in numbers and activity of stem cells may help to maintain health during ageing. Finally, stem cells could be used to renew damaged tissues and replace missing cells in certain disorders.The Cambridge Stem Cell Institute is being formed to explore and define the properties of stem cells and establish their true medical potential. Leading research scientists, technology specialists and doctors will work side by side to create a world-leading centre of excellence in stem cell biology and medicine. The Institute will also collaborate with bioindustry and will provide high level training for young researchers from around the world.

Wellcome Trust MRC剑桥干细胞研究所主任：Austin Smith教授，剑桥大学干细胞科学提供了一系列关于我们的身体是如何形成和维持的新知识。这项研究为更好地了解干细胞带来了希望，这将导致未来的医学应用。治疗可以通过几种途径进行。首先，在实验室中培养的人类干细胞可用于制造病变组织的实验模型和测试治疗药物。其次，一些疾病，包括各种形式的癌症，与干细胞的异常行为有关。当我们学会如何控制干细胞，就有可能纠正这些错误。第三，找到防止干细胞数量和活性下降的方法，可能有助于在衰老过程中保持健康。最后，干细胞可用于更新受损组织和替换某些疾病中缺失的细胞。剑桥干细胞研究所正在成立，以探索和定义干细胞的特性，并确定其真正的医学潜力。领先的研究科学家、技术专家和医生将并肩工作，创建一个世界领先的干细胞生物学和医学卓越中心。该研究所还将与生物产业合作，并将为来自世界各地的年轻研究人员提供高水平的培训。

项目成果

Prediction of acute myeloid leukaemia risk in healthy individuals.

在健康个体中预测急性髓样白血病的风险。

• DOI: 10.1038/s41586-018-0317-6
• 发表时间: 2018-07
• 期刊: Nature
• 影响因子: 64.8
• 作者: Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
• 通讯作者: Shlush LI

Oesophageal Stem Cells and Cancer.

食管干细胞和癌症。

• DOI: 10.1007/978-3-319-69194-7_10
• 发表时间: 2017
• 期刊: Advances in experimental medicine and biology
• 作者: Alcolea MP

Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome.

• DOI: 10.1038/s41598-020-73802-w
• 发表时间: 2020-10-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Aalders J;Léger L;Van der Meeren L;Van den Vreken N;Skirtach AG;Sinha S;De Backer J;van Hengel J
• 通讯作者: van Hengel J

Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.

• DOI: 10.1158/1541-7786.mcr-20-0693
• 发表时间: 2020-12
• 期刊: Molecular cancer research : MCR
• 作者: Ali FR;Marcos D;Chernukhin I;Woods LM;Parkinson LM;Wylie LA;Papkovskaia TD;Davies JD;Carroll JS;Philpott A
• 通讯作者: Philpott A

Prediction of acute myeloid leukaemia risk in healthy individuals

健康个体急性髓性白血病风险的预测

• DOI: 10.17863/cam.30393
• 发表时间: 2018
• 作者: Abelson S