High-throughput NMR metabolic profiling to enhance understanding of mammalian gene function in knockout models generated by the International Mouse Phenotyping Consortium

高通量核磁共振代谢分析可增强对国际小鼠表型联盟生成的基因敲除模型中哺乳动物基因功能的了解

• 批准号: MC_PC_13045
• 负责人: Tertius Hough
• 金额: $ 9.3万
• 依托单位: MRC Harwell Institute
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_13045
• 关键词: throughput; NMR; metabolic; profiling; enhance

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Chronically elevated branched chain amino acid levels are pro-arrhythmic.

• DOI: 10.1093/cvr/cvab207
• 发表时间: 2022-06-22
• 期刊: Cardiovascular research
• 影响因子: 10.8

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

血浆的 H NMR 代谢分析揭示了基因敲除小鼠模型中的其他表型。

• DOI: 10.1021/pr501039k
• 发表时间: 2015
• 期刊: Journal of proteome research
• 影响因子: 4.4
• 作者: Probert F