NEUROPHARMACOLOGY OF COGNITION AND MOOD IN GERIATRIC NEUROPSYCHIATRY

老年神经精神病学中认知和情绪的神经药理学

• 批准号: 4696326
• 负责人: T SUNDERLAND
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696326
• 关键词: Alzheimer's disease; MAO inhibitors; aging; anticholinergic agent; anxiety; arecoline; behavior test; cholinergic agents; depression; dosage; human old age (65+); human subject; memory disorders; naloxone; neuropharmacology; neuropsychological tests; nicotine; psychopharmacology; psychophysiology; scopolamine

Previous work from the Neuropharmacology of Cognition project has addressed the close association between attention and motivational state of depressed patients and normals with their cognitive performance. Testing with intravenous naloxone has demonstrated that behavioral changes such as increased depression and anxiety can lead to impaired memory performance. Those observations have led us to expansion in our investigations examining the effects of neuropharmacologic manipulations on the affective and cognitive responses of Alzheimer's patients. This year, we have observed that these patients show marked cognitive and affective sensitivity to the cholinergic antagonist scopolamine and that the behavioral response of Alzheimer patients to naloxone is at a lower dose than previously found with young normals. We are currently examining the effect of age on the response to scopolamine and maloxone with a cohort of aged controls. We are also now in the initial stages of testing the cognitive, behavioral and neuroendocrine reactions of Alsheimer patients and controls to the cholinergic agonists, arecholine and nicotine. In our continued efforts to explore the links between cognition and affective state and its neuropharmacology, we are also actively investigating a therapeutic drug strategy with monoamine oxidase inhibitors in this population of dementia patients.

认知项目神经药理的先前工作已经解决 注意力与沮丧的动机状态之间的密切联系 患者和正常人的认知表现。 测试 静脉注射纳洛酮已经证明了行为变化，例如 抑郁症和焦虑的增加可能导致记忆力受损。 这些观察结果使我们在研究调查中扩展了 神经药物操纵对情感和 阿尔茨海默氏症患者的认知反应。 今年，我们观察到 这些患者表现出明显的认知和情感敏感性 胆碱能拮抗剂copolamine及其行为反应 阿尔茨海默氏症患者到纳洛酮的剂量低于先前发现的 与年轻的正常人。 我们目前正在研究年龄对 对西侧骨pol碱和马毒的反应，并具有一系列老年对照组。 我们 现在也处于测试认知，行为和 Alsheimer患者的神经内分泌反应和对照 胆碱能激动剂，六烯和尼古丁。 在我们持续的努力中 探索认知与情感状态及其它的联系 神经药理学，我们也在积极研究治疗药物 在这种痴呆群中，单胺氧化酶抑制剂的策略 患者。