SPONTANEOUS PROGRESSION OF LEFT VENTRICULAR HYPERTROPHY DURING ADOLESCENCE IN HCM

HCM 青少年时期左心室肥大的自发进展

• 批准号: 4694674
• 负责人: B J MARON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694674
• 关键词: adolescence (12-20); echocardiography; heart disorder diagnosis; human subject; hypertrophic myocardiopathy; longitudinal human study

Twenty-one relatives of patients with documented hypertrophic cardiomyopathy were studied prospectively over a period of 5 years with M-mode and wide-angle two-dimensional echocardiography to evaluate the potential for progression of left ventricular hypertrophy. Although each of these subjects had no or minimal hypertrophy prior to adolescence, 11 showed marked increase in the magnitude and distribution of hypertrophy including 3 who progressed from a normal heart. These findings also emphasize that echocardiographic screening of pre-adolescent family members cannot definitively exclude hypertrophic cardiomyopathy.

21例记录在案的肥厚症患者的亲属 对心肌病进行了为期5年的前瞻性研究 M型和广角二维超声心动图评价二尖瓣狭窄 左心室肥厚进展的可能性。尽管每个人 在这些受试者中，有11人在青春期前没有肥大或有轻微肥大 显示肥大的程度和分布明显增加 其中3例心脏正常进展。这些发现还包括 强调对青春期前家庭成员的超声心动图筛查 不能明确排除肥厚型心肌病。