肾上腺素能系统在乙酰胆碱引起的狗血管收缩中的作用-猫眼课题宝

肾上腺素能系统在乙酰胆碱引起的狗血管收缩中的作用

批准号：

4694555

负责人：

J YUN

金额：

$0.0万

依托单位：

NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/4694555

关键词：

acetylcholine cholinergic agents excretion indomethacin intraarterial administration kidney function kidney pharmacology neuropharmacology neurotransmitters propranolol renal hypertension renin angiotensin system reserpine saluresis saralasin sodium vasoconstriction vasoconstrictors

中文摘要

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英文摘要

The role of the renin-angiotensin system in the renal vasoconstriction by acetylocholine (ACh) in indomethacin (INDO)-treated dogs was examined in dogs receiving infusion of either saralasin, an angiotensin II blocker (intrarenal), saralasin and phenoxybenzamine (intrarenal) or propranolol (I.V.) In INDO-treated dogs receiving an infusion of saralasin alone or in combination with phenoxybenzamine and propranolol, renal arterial infusion of ACh produced an initial rise in sodium excretion (UNaV) and renal plasma flow (RPF) with no change in renin secretion (RS). This was followed by a fall in UNaV and RPF with an increase in RS. It is concluded that ACh produces renal vasoconstriction in INDO-treated dogs by mechanism(s) other than an increase in the activity of the renin-angiotensin system.

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