ROLE OF ADRENERGIC SYSTEM IN VASOCONSTRICTION BY ACETYLCHOLINE IN DOGS

肾上腺素能系统在乙酰胆碱引起的狗血管收缩中的作用

• 批准号: 4694555
• 负责人: J YUN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694555
• 关键词: acetylcholine; cholinergic agents; excretion; indomethacin; intraarterial administration; kidney function; kidney pharmacology; neuropharmacology; neurotransmitters; propranolol; renal hypertension; renin angiotensin system; reserpine; saluresis; saralasin; sodium; vasoconstriction; vasoconstrictors

The role of the renin-angiotensin system in the renal vasoconstriction by acetylocholine (ACh) in indomethacin (INDO)-treated dogs was examined in dogs receiving infusion of either saralasin, an angiotensin II blocker (intrarenal), saralasin and phenoxybenzamine (intrarenal) or propranolol (I.V.) In INDO-treated dogs receiving an infusion of saralasin alone or in combination with phenoxybenzamine and propranolol, renal arterial infusion of ACh produced an initial rise in sodium excretion (UNaV) and renal plasma flow (RPF) with no change in renin secretion (RS). This was followed by a fall in UNaV and RPF with an increase in RS. It is concluded that ACh produces renal vasoconstriction in INDO-treated dogs by mechanism(s) other than an increase in the activity of the renin-angiotensin system.

肾素-血管紧张素系统在肾血管收缩中的作用 在吲哚美辛（INDO）治疗的狗中检测了乙酰胆碱（ACh）， 接受saralasin（一种血管紧张素II阻滞剂）输注的犬 （肾内）、沙拉新和酚苄明（肾内）或普萘洛尔 （静脉注射） 在接受单独输注saralasin或联合输注saralasin的INDO治疗犬中， 复方酚苄明和普萘洛尔，肾动脉灌注 ACh产生的钠排泄（UNaV）和肾血浆中的初始上升 血浆肾素分泌（RS）无变化。 随后是 联合国志愿人员和卢旺达爱国阵线的人数下降，而斯普斯卡共和国的人数增加。 结论：ACh 通过机制在INDO治疗犬中产生肾血管收缩其他 而不是增加肾素-血管紧张素系统的活性。