瑞纳吃狗-猫眼课题宝

瑞纳吃狗

批准号：

3966597

负责人：

J YUN

金额：

$0.0万

依托单位：

NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3966597

关键词：

acetylcholine cardiovascular pharmacology cyclic AMP dosage hypertension indomethacin intraarterial administration kidney pharmacology renin saluresis secretion vascular smooth muscle vasoconstriction verapamil

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中文摘要

翻译

乙酰胆碱致肾血管收缩的机制

英文摘要

The mechanism for the renal vasoconstriction induced by acetylocholine (ACh) in idomethacin (Indo)-treated dogs was examined in dogs receiving an infusion of either verapamil (V) or dibutyryl cyclic AMP (db-AMP). Renal arterial infusion of V (60 ug/min) attenuated, but did not eliminate, the fall in renal plasma flow induced by ACh (40 ug/min) in Indo-treated dogs (5 mg/kg). Renin secretory rate, however, did not show a rise. Renal arterial infusion of db-cAMP (6 mg/min) restored the natriuretic and vasodilatory effects of ACh in Indo-treated dogs. The data suggest that ACh causes an increase in intracellular CA++ concentration by stimulating Ca++ influx and the release of Ca++ from intracellular storage sites in Indo-treated dogs. The increase in cytosolic Ca++ concentration then leads to contraction of vascular smooth muscle resulting in renal vasoconstriction.

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