ROLE OF PROSTAGLANDIN I2 IN THE RENAL VASODILATATION INDUCED BY ACETYLCHOLINE

前列腺素 I2 在乙酰胆碱诱导的肾血管舒张中的作用

• 批准号: 3920134
• 负责人: J YUN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920134
• 关键词: acetylcholine; dogs; glomerular filtration; indomethacin; intravenous administration; kidney circulation; prostaglandins; renin; saluresis; secretion; sodium; vasodilation

The role of prostaglandin I2 (PGI2) in the renal vasodilatation induced by acetylcholine (ACh) was examined in indomethacin (Indo)treated dogs receiving an infusion of PGI2. Renal arterial infusion of ACh (40mug/min) in control dogs produced an increase in sodium excretion and renal plasma flow (RPF) without a change in glomerular filtration rate (GFR) or renin secretory rate (RSR). In dogs pretreated with indomethacin (Indo), an inhibitor of prostaglandin synthesis, renal arterial infusion of ACh produced an increase and then a decline in sodium excretion accompanied by a progressive fall in GFR and RPF and a progressive rise in RSR. Renal arterial infusion of PGI2 (0.2mug/min) before and during the infusion of ACh restored the natriuretic and vasodilatory response to ACh in Indo-treated dogs. The data suggest that Indo shortens the natriuretic and vasodilatory response to ACh by inhibiting synthesis of prostaglandins, possibly PGI2, and that PGI2 may play a role in the renal vasodilatory effect of ACh.

前列腺素 I2 (PGI2) 在肾血管舒张中的作用 在吲哚美辛中检查了乙酰胆碱 (ACh) 诱导的 （印度）治疗的狗接受 PGI2 输注。 肾动脉 对照狗输注乙酰胆碱（40 微克/分钟）可增加 钠排泄和肾血浆流量 (RPF) 没有变化 肾小球滤过率（GFR）或肾素分泌率（RSR）。 在用吲哚美辛（Indo）预处理的狗中，吲哚美辛是一种抑制剂 前列腺素合成，肾动脉输注产生乙酰胆碱 钠排泄先增加后减少 GFR 和 RPF 逐渐下降，RSR 逐渐上升。 术前和术中肾动脉输注 PGI2（0.2 微克/分钟） 输注乙酰胆碱可恢复利尿钠和血管舒张反应 经印度处理的狗体内的乙酰胆碱。 数据显示印度缩短 通过抑制对 ACh 的利尿钠和血管舒张反应 前列腺素（可能是 PGI2）的合成，PGI2 可能发挥作用 ACh 的肾血管舒张作用发挥作用。