NERBL Core 3: Biocontainment Research Support Services
NERBL 核心 3:生物防护研究支持服务
基本信息
- 批准号:10793934
- 负责人:
- 金额:$ 42.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-18 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAerosolsAnimal ModelAnimalsAreaBacteriologyBiological ModelsBiologyCommunitiesCompetenceComplementCulicidaeDevelopmentDiagnosisDiseaseEastern Equine EncephalomyelitisEmergency responseEnsureEvolutionExperimental Animal ModelFree WillGeneticGenetic VariationGoalsHumanImmunologic MarkersImmunologyImmunology procedureIndustryInfectionInfectious AgentInfectious Diseases ResearchInfluenzaInterventionKnowledgeLaboratoriesLaboratory ResearchMaintenanceMethodologyModelingMycobacterium tuberculosisNational Institute of Allergy and Infectious DiseaseNew EnglandOutcomePathologyPhenotypePowassan encephalitisPowassan virusPreclinical TestingPreparationProceduresProteomicsPublic HealthResearchResearch PersonnelResearch SupportResource DevelopmentResourcesRodent ModelSamplingServicesTechnologyTick-Borne DiseasesTicksTimeTrainingTuberculosisTularemiaUnited States National Institutes of HealthVariantViralVirulenceVirusWorkWorkforce DevelopmentZoonosesbiobankdesigneffective interventionexperiencegenomic dataimprovedindustry partnerinfluenzavirusmedical countermeasuremeetingsmembermouse modelnew pandemicnoveloperationpandemic pathogenpandemic potentialpandemic preparednesspandemic responsepathogenpre-clinicalpreventprogramsresearch clinical testingrespiratoryrespiratory virusresponsescreeningskillstick transmissiontranscriptomicstransmission processvaccine developmentvectorvector transmissionvirologyvirtual
项目摘要
PROJECT SUMMARY – CORE 3
The New England Regional Biosafety Laboratory (NERBL) was established in 2008 to: (1) ensure that
research and tasks in response to pathogens of pandemic potential and other emerging infections (PPP/EI) are
safely, efficiently, and rigorously accomplished; (2) serve as a regional resource for academic and industry
partners engaged in activities that yield knowledge and medical countermeasures to PPP/EI; and (3) be ready
to serve as directed by NIH/NIAID and their federal partners. A critical function of the NERBL includes the
development and continuous improvement of specialized research functions unique to BSL3/ABSL3,
particularly those focused on pathogens with human impact. At Tufts, existing expertise and knowledge
bridges several areas of emphasis including bacteriology (tuberculosis [Mtb]), virology (influenza), and vector-
pathogen interactions (eastern equine and Powassan encephalitis, tularemia). Building upon these
fundamental capacities, the primary goal of Core 3 is to optimize and expand BSL3/ABSL3 resources
and services for academic, industry and federal researchers to address both regional and national
needs. Additionally, Core 3 will provide research services, training, and expertise across the larger Regional
Biocontainment Laboratories network while also developing, validating and distributing standard operating
procedures for conducting BSL3/ABSL3 research. To accomplish this, we will optimize core capacities for Mtb
research, optimize core capacities for influenza research, enhance expertise in vector-pathogen interaction
research, and grow core competencies through the larger RBL Network partnership. This work is supported
by a set of team members with several key skills necessary for undertaking studies that involve Mtb, influenza,
and tick-borne disease, including: 1) propagation and isolation of pathogens; 2) use of several experimental
animal model system including tick challenge models; 3) application of medical countermeasure screening; 4)
use of various aerobiology methodologies; 5) assessment of immunologic biomarkers/outcomes associated
with infectious agents; and 6) integration of pathology and genomic data, including spatial
transcriptomics/proteomics. Together, completion of these specific aims will strengthen the overall RBL
collaborative with respect to collective expertise and capacities necessary for robust PPP/EI responsiveness,
and provide a toolbox of resources for the larger infectious disease research community.
项目概要-核心3
新英格兰地区生物安全实验室(NERBL)成立于2008年,旨在:(1)确保
针对潜在大流行病原体和其他新发感染(PPP/EI)的研究和任务包括:
安全,高效,严格完成;(2)作为学术和工业的区域资源
参与PPP/EI知识和医疗对策活动的合作伙伴;(3)做好准备
由NIH/NIAID及其联邦合作伙伴指导。NERBL的关键功能包括
开发和不断改进BSL 3/ABSL 3独有的专业研究功能,
特别是那些关注对人类有影响的病原体的研究。在塔夫茨,现有的专业知识和知识
连接了几个重点领域,包括细菌学(结核病[Mtb])、病毒学(流感)和病媒-
病原体相互作用(东部马和Powassan脑炎,兔热病)。在此基础上,
核心3的主要目标是优化和扩展BSL 3/ABSL 3资源
为学术界、工业界和联邦研究人员提供服务,
需求此外,核心3将提供研究服务,培训和专业知识,在更大的区域
生物防护实验室网络,同时还开发,验证和分发标准操作
进行BSL 3/ABSL 3研究的程序。为了实现这一目标,我们将优化Mtb的核心能力
研究,优化流感研究的核心能力,加强病媒-病原体相互作用方面的专门知识
研究,并通过更大的RBL网络伙伴关系发展核心竞争力。资助项目
由一组具有进行涉及结核分枝杆菌,流感,
和蜱传疾病,包括:1)病原体的繁殖和分离; 2)使用几种实验
包括蜱攻击模型的动物模型系统; 3)医学对策筛选的应用; 4)
使用各种空气生物学方法; 5)评估相关的免疫生物标志物/结局
与感染因子;和6)整合病理学和基因组数据,包括空间
转录组学/蛋白质组学。总之,完成这些具体目标将加强总体的成果预算制
* 在强有力的公私伙伴关系/环境倡议响应所需的集体专门知识和能力方面进行协作,
并为更大的传染病研究社区提供资源工具箱。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Sam R Telford', 18)}}的其他基金
NERBL Core 1: Facility Management, Maintenance and Operations
NERBL 核心 1:设施管理、维护和运营
- 批准号:
10793932 - 财政年份:2023
- 资助金额:
$ 42.36万 - 项目类别:
Facility Upgrade for the New England Regional Biosafety Laboratory
新英格兰地区生物安全实验室设施升级
- 批准号:
10630474 - 财政年份:2022
- 资助金额:
$ 42.36万 - 项目类别:
Facility Upgrade for the New England Regional Biosafety Laboratory
新英格兰地区生物安全实验室设施升级
- 批准号:
10394468 - 财政年份:2021
- 资助金额:
$ 42.36万 - 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
- 批准号:
10211119 - 财政年份:2018
- 资助金额:
$ 42.36万 - 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
- 批准号:
9756305 - 财政年份:2018
- 资助金额:
$ 42.36万 - 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
- 批准号:
9976450 - 财政年份:2018
- 资助金额:
$ 42.36万 - 项目类别:
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