NERBL Core 3: Biocontainment Research Support Services

NERBL 核心 3:生物防护研究支持服务

基本信息

  • 批准号:
    10793934
  • 负责人:
  • 金额:
    $ 42.36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-18 至 2028-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY – CORE 3 The New England Regional Biosafety Laboratory (NERBL) was established in 2008 to: (1) ensure that research and tasks in response to pathogens of pandemic potential and other emerging infections (PPP/EI) are safely, efficiently, and rigorously accomplished; (2) serve as a regional resource for academic and industry partners engaged in activities that yield knowledge and medical countermeasures to PPP/EI; and (3) be ready to serve as directed by NIH/NIAID and their federal partners. A critical function of the NERBL includes the development and continuous improvement of specialized research functions unique to BSL3/ABSL3, particularly those focused on pathogens with human impact. At Tufts, existing expertise and knowledge bridges several areas of emphasis including bacteriology (tuberculosis [Mtb]), virology (influenza), and vector- pathogen interactions (eastern equine and Powassan encephalitis, tularemia). Building upon these fundamental capacities, the primary goal of Core 3 is to optimize and expand BSL3/ABSL3 resources and services for academic, industry and federal researchers to address both regional and national needs. Additionally, Core 3 will provide research services, training, and expertise across the larger Regional Biocontainment Laboratories network while also developing, validating and distributing standard operating procedures for conducting BSL3/ABSL3 research. To accomplish this, we will optimize core capacities for Mtb research, optimize core capacities for influenza research, enhance expertise in vector-pathogen interaction research, and grow core competencies through the larger RBL Network partnership. This work is supported by a set of team members with several key skills necessary for undertaking studies that involve Mtb, influenza, and tick-borne disease, including: 1) propagation and isolation of pathogens; 2) use of several experimental animal model system including tick challenge models; 3) application of medical countermeasure screening; 4) use of various aerobiology methodologies; 5) assessment of immunologic biomarkers/outcomes associated with infectious agents; and 6) integration of pathology and genomic data, including spatial transcriptomics/proteomics. Together, completion of these specific aims will strengthen the overall RBL collaborative with respect to collective expertise and capacities necessary for robust PPP/EI responsiveness, and provide a toolbox of resources for the larger infectious disease research community.
项目概要-核心3 新英格兰地区生物安全实验室(NERBL)成立于2008年,旨在:(1)确保 针对潜在大流行病原体和其他新发感染(PPP/EI)的研究和任务包括: 安全,高效,严格完成;(2)作为学术和工业的区域资源 参与PPP/EI知识和医疗对策活动的合作伙伴;(3)做好准备 由NIH/NIAID及其联邦合作伙伴指导。NERBL的关键功能包括 开发和不断改进BSL 3/ABSL 3独有的专业研究功能, 特别是那些关注对人类有影响的病原体的研究。在塔夫茨,现有的专业知识和知识 连接了几个重点领域,包括细菌学(结核病[Mtb])、病毒学(流感)和病媒- 病原体相互作用(东部马和Powassan脑炎,兔热病)。在此基础上, 核心3的主要目标是优化和扩展BSL 3/ABSL 3资源 为学术界、工业界和联邦研究人员提供服务, 需求此外,核心3将提供研究服务,培训和专业知识,在更大的区域 生物防护实验室网络,同时还开发,验证和分发标准操作 进行BSL 3/ABSL 3研究的程序。为了实现这一目标,我们将优化Mtb的核心能力 研究,优化流感研究的核心能力,加强病媒-病原体相互作用方面的专门知识 研究,并通过更大的RBL网络伙伴关系发展核心竞争力。资助项目 由一组具有进行涉及结核分枝杆菌,流感, 和蜱传疾病,包括:1)病原体的繁殖和分离; 2)使用几种实验 包括蜱攻击模型的动物模型系统; 3)医学对策筛选的应用; 4) 使用各种空气生物学方法; 5)评估相关的免疫生物标志物/结局 与感染因子;和6)整合病理学和基因组数据,包括空间 转录组学/蛋白质组学。总之,完成这些具体目标将加强总体的成果预算制 * 在强有力的公私伙伴关系/环境倡议响应所需的集体专门知识和能力方面进行协作, 并为更大的传染病研究社区提供资源工具箱。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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专利数量(0)

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Sam R Telford其他文献

Sam R Telford的其他文献

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{{ truncateString('Sam R Telford', 18)}}的其他基金

NERBL Core 1: Facility Management, Maintenance and Operations
NERBL 核心 1:设施管理、维护和运营
  • 批准号:
    10793932
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
NERBL Core 2: BSL-3 Practices
NERBL 核心 2:BSL-3 实践
  • 批准号:
    10793933
  • 财政年份:
    2023
  • 资助金额:
    $ 42.36万
  • 项目类别:
Facility Upgrade for the New England Regional Biosafety Laboratory
新英格兰地区生物安全实验室设施升级
  • 批准号:
    10630474
  • 财政年份:
    2022
  • 资助金额:
    $ 42.36万
  • 项目类别:
Facility Upgrade for the New England Regional Biosafety Laboratory
新英格兰地区生物安全实验室设施升级
  • 批准号:
    10394468
  • 财政年份:
    2021
  • 资助金额:
    $ 42.36万
  • 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
  • 批准号:
    10211119
  • 财政年份:
    2018
  • 资助金额:
    $ 42.36万
  • 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
  • 批准号:
    9756305
  • 财政年份:
    2018
  • 资助金额:
    $ 42.36万
  • 项目类别:
Retrotransposon assay for tick host bloodmeal identification
用于蜱宿主血粉鉴定的逆转录转座子测定
  • 批准号:
    9976450
  • 财政年份:
    2018
  • 资助金额:
    $ 42.36万
  • 项目类别:
Perpetuation of Francisella tularensis
土拉弗朗西斯菌的永存
  • 批准号:
    7350858
  • 财政年份:
    2006
  • 资助金额:
    $ 42.36万
  • 项目类别:
Perpetuation of Francisella tularensis
土拉弗朗西斯菌的永存
  • 批准号:
    7168845
  • 财政年份:
    2006
  • 资助金额:
    $ 42.36万
  • 项目类别:
Perpetuation of Francisella tularensis
土拉弗朗西斯菌的永存
  • 批准号:
    7036059
  • 财政年份:
    2006
  • 资助金额:
    $ 42.36万
  • 项目类别:

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